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Prognostic Factors for Disease-Free Survival in pT2N0 Non-Small Cell Lung Cancer

Authors
 Inkyu Park  ;  Kyung Young Chung  ;  Kil Dong Kim  ;  Dae Joon Kim 
Citation
 Asian Cardiovascular and Thoracic Annals, Vol.14(2) : 139-144, 2006 
Journal Title
 Asian Cardiovascular and Thoracic Annals 
ISSN
 0218-4923 
Issue Date
2006
MeSH
Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/mortality* ; Carcinoma, Non-Small-Cell Lung/therapy* ; Chemotherapy, Adjuvant ; Cohort Studies ; Disease-Free Survival ; Female ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/mortality* ; Lung Neoplasms/therapy* ; Male ; Middle Aged ; Pneumonectomy* ; Retrospective Studies ; Survival Rate ; Tegafur ; Treatment Outcome ; Uracil
Abstract
To clarify the prognostic factors for disease-free survival in completely resected pT2N0 non-small cell lung cancer, 81 consecutive patients who were treated between 1998 and 2001 were retrospectively reviewed. Follow-up was complete for all patients and the median follow-up time was 37.5 months. The overall 5-year survival rate was 68.6%, and the 5-year disease-free survival rate was 62.5%. Four factors (age, sex, visceral pleural invasion, and administration of tegafur and uracil) were proposed as prognostic factors for disease-free survival by univariate analysis. In multivariate analysis, visceral pleural invasion by the tumor (hazard ratio = 2.709, 95% confidence interval: 1.085 to 6.765, p = 0.033) and administration of tegafur and uracil (hazard ratio = 0.327, 95% confidence interval: 0.147 to 0.730, p = 0.006) were significant factors. Visceral pleural invasion was a prognostic factor for reduced disease-free survival in completely resected pT2N0 non-small cell lung cancer, and postoperative treatment with tegafur and uracil significantly improved disease-free survival.
Full Text
http://aan.sagepub.com/content/14/2/139.long
DOI
10.1177/021849230601400212
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Park, In Kyu(박인규)
Chung, Kyung Young(정경영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109159
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