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Anatomy and physiology of the basal ganglia: Implications for deep brain stimulation for Parkinson's disease

Authors
 Brian H. Kopell  ;  Ali R. Rezai  ;  Jin Woo Chang  ;  Jerrold L. Vitek 
Citation
 MOVEMENT DISORDERS, Vol.21(SUPPL14) : 238-246, 2006 
Journal Title
MOVEMENT DISORDERS
ISSN
 0885-3185 
Issue Date
2006
MeSH
Basal Ganglia/anatomy & histology* ; Basal Ganglia/physiology* ; Cerebral Cortex/anatomy & histology ; Cerebral Cortex/physiology ; Corpus Striatum/physiology ; Deep Brain Stimulation/methods* ; Globus Pallidus/physiology ; Humans ; Parkinson Disease/therapy* ; Substantia Nigra/physiology ; Thalamus/physiology
Abstract
Central to surgical management of movement disorders is an understanding of the anatomy and physiology of the basal ganglia. The basal ganglia have been a target for neuromodulation surgery since Russell Meyers' pioneering works in the late 1930s. With the development of deep brain stimulation as the gold standard of surgical intervention for movement disorders, there has been a concomitant evolution in the understanding of the role the basal ganglia plays in the genesis of normal and abnormal motor behaviors. The fundamental concept of the cortico–striato–pallido–thalamocortical loop will be explored in the context of deep brain stimulation. The current targets for deep brain stimulation for Parkinson's disease, the subthalamic nucleus, the globus pallidus internus, and the ventral intermediate nucleus, will be discussed in the framework of the current physiological and anatomical models of Parkinson's disease (PD). Finally, the current understandings of the mechanisms underpinning the beneficial effects of deep brain stimulation for PD will be discussed.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mds.20958/abstract
DOI
10.1002/mds.20958
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109118
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