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Forinx Integrity and Hippocampal Volume in Male Schizophrenic Patients

Authors
 Noriomi Kuroki  ;  Marek Kubicki  ;  Paul G. Nestor  ;  Dean F. Salisbury  ;  Hae-Jeong Park  ;  James J. Levitt  ;  Sophie Woolston  ;  Melissa Frumin  ;  Margaret Niznikiewicz  ;  Carl-Fredrik Westin  ;  Stephan E. Maier  ;  Robert W. McCarley  ;  Martha E. Shenton 
Citation
 BIOLOGICAL PSYCHIATRY, Vol.60(1) : 22-31, 2006 
Journal Title
BIOLOGICAL PSYCHIATRY
ISSN
 0006-3223 
Issue Date
2006
MeSH
Adult ; Anisotropy ; Brain Mapping* ; Diffusion Magnetic Resonance Imaging/methods ; Fornix, Brain/pathology* ; Functional Laterality/physiology ; Hippocampus/pathology* ; Humans ; Image Processing, Computer-Assisted/methods ; Male ; Middle Aged ; Schizophrenia/pathology* ; Statistics, Nonparametric
Keywords
Anisotropy ; diffusion tensor imaging ; fornix ; hippocampus ; MRI ; white matter
Abstract
BACKGROUND: The hippocampus has been shown to be abnormal in schizophrenia. The fornix is one of the main fiber tracts connecting the hippocampus with other brain regions. Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia. METHODS: Line-scan diffusion tensor imaging (DTI) was used to evaluate diffusion in the fornix in 24 male patients with chronic schizophrenia and 31 male control subjects. Maps of fractional anisotropy (FA) and mean diffusivity (D(m)), which are indices sensitive to white-matter integrity, were generated to quantify diffusion within the fornix. We used high spatial resolution magnetic resonance imaging (MRI) to measure hippocampal volume. RESULTS: FA and cross-sectional area of the fornix were significantly reduced in patients compared with control subjects. D(m) was significantly increased, whereas hippocampal volume was bilaterally reduced in patients. Reduced hippocampal volume was correlated with increased mean D(m) and reduced cross-sectional area of the fornix for patients. Patients also showed a significant correlation between reduced scores on neuropsychologic measures of declarative-episodic memory and reduced hippocampal volumes. CONCLUSIONS: These findings demonstrate a disruption in fornix integrity in patients with schizophrenia.
Files in This Item:
T200600288.pdf Download
DOI
10.1016/j.biopsych.2005.09.021
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109098
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