Multinucleation of koilocytes is actually multilobation

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Authors: N.H. CHO ; S. KANG ; S. HONG ; G.B. JEONG ; I.W. CHOI ; H.J. CHOI ; H.K. CHOI

Citation: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol.16(2) : 686-689, 2006

MeSH: Cell Nucleus/metabolism ; Cell Nucleus/pathology ; Cervical Intraepithelial Neoplasia/genetics ; Cervical Intraepithelial Neoplasia/ultrastructure ; Cervical Intraepithelial Neoplasia/virology* ; Female ; Genotype ; Humans ; Imaging, Three-Dimensional ; Microscopy, Confocal ; Papillomaviridae/classification ; Papillomaviridae/genetics ; Papillomaviridae/isolation & purification* ; Papillomavirus Infections/complications* ; Papillomavirus Infections/pathology ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/ultrastructure ; Uterine Cervical Neoplasms/virology*

Abstract: In order to clarify the complete cytomorphology of cytopathic changes as a consequence of human papillomavirus (HPV) infection, we performed three-dimensional (3D) reconstruction from confocal fluorescent images. After confirming 22 HPV types using a DNA chip, we performed 3D confocal image restoration in human uterine cervical swab samples and corresponding tumor tissues. On restoration of 3D confocal images, the multinucleated feature of koilocytes was revealed to be multilobation of a single nucleus, as opposed to true multinucleation.

Full Text: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00009577-200603000-00037&LSLINK=80&D=ovft

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

Yonsei Authors: Cho, Nam Hoon(조남훈) https://orcid.org/0000-0002-0045-6441
Hong, Soon Won(홍순원) https://orcid.org/0000-0002-0324-2414

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