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Synergistic Effect of Staphylococcus aureus and LPS on Silica-Induced Tumor Necrosis Factor Production in Macrophage Cell Line J774A.1

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dc.contributor.author박종철-
dc.date.accessioned2015-06-10T12:00:23Z-
dc.date.available2015-06-10T12:00:23Z-
dc.date.issued2006-
dc.identifier.issn1017-7825-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/109018-
dc.description.abstractIn this study, we investigated the synergistic effects of Staphylococcus aureus extracts (membranes and walls) and lipopolysaccharide (LPS) derived from Escherichia coli on tumor necrosis factor (TNF) production in the pathogenesis of silica-induced inflammation. The synergistic induction of TNF by silica particles (<20 μm) in combination with either S. aureus extracts or LPS was examined in J774A.1 cell cultures. Media from the treated and untreated cell cultures were assayed for TNF, using the mouse WEHI 164 cell cytotoxicity assay and enzyme immunoassay. Cells exposed simultaneously to silica and 0.5 μg/ml S. aureus extracts (or 0.5 ng/ml of LPS) produced a significantly higher level of TNF than those produced by the inducer alone. Our results indicate that device-associated infections (or pyrogen contamination) could enhance inflammatory responses, because of particles produced by the wear of medical implants or particulate biomaterials used for clinical purposes.-
dc.description.statementOfResponsibilityopen-
dc.format.extent136~140-
dc.relation.isPartOfJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSynergistic Effect of Staphylococcus aureus and LPS on Silica-Induced Tumor Necrosis Factor Production in Macrophage Cell Line J774A.1-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학)-
dc.contributor.googleauthorLee, Dong Hee-
dc.contributor.googleauthorBong Joo Park-
dc.contributor.googleauthorMin Sub Lee-
dc.contributor.googleauthorJae Bong Choi-
dc.contributor.googleauthorJeong Koo Kim-
dc.contributor.googleauthorJong Hoon Park-
dc.contributor.googleauthorJong-Chul Park-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01662-
dc.relation.journalcodeJ01594-
dc.identifier.eissn1738-8872-
dc.subject.keywordSynergistic effect-
dc.subject.keywordStaphylococcus aureus-
dc.subject.keywordlipopolysaccharide-
dc.subject.keywordtumor necrosis factor-
dc.subject.keywordsilica-
dc.subject.keywordmacrophage-
dc.subject.keywordphagocytosis-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.rights.accessRightsfree-
dc.citation.volume16-
dc.citation.number1-
dc.citation.startPage136-
dc.citation.endPage140-
dc.identifier.bibliographicCitationJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, Vol.16(1) : 136-140, 2006-
dc.identifier.rimsid53715-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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