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Complete stable remission after extended transsternal thymectomy in myasthenia gravis

Authors
 In Kyu Park  ;  Sung Sil Choi  ;  Jin Gu Lee  ;  Dae Joon Kim  ;  Kyung Young Chung 
Citation
 EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol.30(3) : 525-528, 2006 
Journal Title
 EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 
ISSN
 1010-7940 
Issue Date
2006
MeSH
Adolescent ; Adult ; Aged ; Child ; Female ; Humans ; Male ; Middle Aged ; Myasthenia Gravis/complications ; Myasthenia Gravis/pathology ; Myasthenia Gravis/surgery* ; Neoplasm Staging ; Postoperative Complications ; Retrospective Studies ; Thymectomy/methods* ; Thymoma/complications ; Thymoma/pathology ; Thymoma/surgery ; Thymus Gland/pathology ; Thymus Gland/surgery ; Thymus Neoplasms/complications ; Thymus Neoplasms/pathology ; Thymus Neoplasms/surgery ; Treatment Outcome
Keywords
Myasthenia gravis ; Extended transsternal thymectomy ; Complete stable remission
Abstract
Objective: This study sought to determine the efficacy and prognostic factors of extended transsternal thymectomy as a treatment for myasthenia gravis (MG). Methods: Medical records of 147 patients who underwent extended transsternal thymectomy for MG from January 1991 to December 2002 were reviewed retrospectively. The complete stable remission (CSR) rate and prognostic factors for CSR were assessed in 106 female and 41 male patients. Results: The median age was 35 years (range 11–75 years). Ninety-eight patients had non-thymomatous MG and 49 patients had thymomatous MG. The median follow-up time was 89.7 months (range 12–167 months). Both non-thymomatous MG and thymomatous MG exhibited significant differences in population characteristics and CSR rates (29.6% vs 13.3% at 5 years, 45.2% vs 27.7% at 10 years, p = 0.022). Steroid therapy (hazard ratio: 0.234, p = 0.003) was a poor prognostic factor, while early onset (hazard ratio: 3.519, p = 0.048) was a good prognostic factor for CSR in non-thymomatous MG. In contrast, steroid therapy (hazard ratio: 0.061, p = 0.034) was poor prognostic factor for thymomatous MG. Conclusions: Extended transsternal thymectomy is a good treatment tool to achieve CSR in MG. Thymomatous MG and non-thymomatous MG were significantly different in patient characteristics and prognosis. Prognostic factors were steroid therapy and age of onset in non-thymomatous MG, and steroid therapy in thymomatous MG.
Full Text
http://ejcts.oxfordjournals.org/content/30/3/525.long
DOI
10.1016/j.ejcts.2006.06.009
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Park, In Kyu(박인규)
Chung, Kyung Young(정경영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108964
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