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Coronary Artery Intervention after Cytostatics Treatment in Unstable Angina Patient with Essential Thrombocythemia. A Case Report and Literature Review

Authors
 Hyun Chang  ;  Chi Young Shim  ;  Jung-won Cheong  ;  Ju-yeon Pyo  ;  Young Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  June Won Cheong 
Citation
 KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.21(2) : 146-149, 2006 
Journal Title
 KOREAN JOURNAL OF INTERNAL MEDICINE 
ISSN
 1226-3303 
Issue Date
2006
MeSH
Angina, Unstable/etiology ; Angina, Unstable/therapy* ; Angioplasty, Balloon, Coronary* ; Humans ; Hydroxyurea/therapeutic use ; Male ; Middle Aged ; Quinazolines/therapeutic use ; Stents* ; Thrombocythemia, Essential/complications ; Thrombocythemia, Essential/drug therapy*
Keywords
Angina ; Unstable ; Thrombocytosis ; Antineoplastic agents ; Platelet aggregation inhibitors
Abstract
Essential thrombocythemia (ET) is a clonal disorder of myeloid stem cells that causes thrombocytosis. As a result, ET can lead to vascular thrombosis and tissue ischemia; the association of coronary artery abnormalities such as myocardial infarction or unstable angina is rare. Here we describe a 45-year-old male patient with essential thrombocythemia who presented with unstable angina. Elective coronary angiography showed total occlusion of mid right coronary artery and mid left anterior descending coronary artery. ET was confirmed by a bone marrow biopsy; treatment was started with antiplatelet therapy including aspirin and clopidogrel along with cytostatic therapy with hydroxyurea and anagrelide. After the initiation of the treatment, the platelet count decreased to 20×104/µL. In addition, percutaneous coronary angioplasty was successfully performed with stent placement at the right coronary artery without hemorrhagic or thrombotic complications.
Files in This Item:
T200600134.pdf Download
DOI
10.3904/kjim.2006.21.2.146
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chang, Hyun(장현)
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108916
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