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The relation between birth weight and insulin resistance in Korean adolescents

 Chul-sik Kim  ;  Jong-suk Park  ;  Jina Park  ;  Ji-sun Nam  ;  Eun-seok Kang  ;  Chul-woo Ahn  ;  Bong-soo Cha  ;  Sung-kil Lim  ;  Kyung-rae Kim  ;  Hyun-chul Lee  ;  Kap-bum Huh  ;  Dae-jung Kim 
 YONSEI MEDICAL JOURNAL, Vol.47(1) : 85-92, 2006 
Journal Title
Issue Date
Adolescent ; Birth Weight* ; Blood Pressure ; C-Peptide/blood ; Child ; Female ; Humans ; Hyperinsulinism/epidemiology ; Hyperinsulinism/etiology ; Hyperinsulinism/metabolism ; Insulin/blood ; Insulin Resistance* ; Insulin-Secreting Cells/physiology ; Korea/epidemiology ; Male
Birth weight ; insulin resistance ; adolescence
Low birth weight is associated with insulin resistance and type 2 diabetes in adults. The fetal programming hypothesis has shown that insulin resistance and its associated metabolic disturbances result from a poor gestational environment, for which low birth weight is a surrogate. An at-home questionnaire survey was performed on 660 middle school students (12-15 years) in Seoul, Korea, and 152 cases were randomly selected based on their birth weight. Subjects were divided into three groups according to birth weight. We recorded their birth weight and measured their current anthropometric data, blood pressure, lipid profile, HOMA-IR, and HOMA-β, and compared these parameters among the groups. The relation of birth weight to physiological characteristics in adolescence was examined. Systolic blood pressure, lipid profiles, and fasting plasma glucose, HOMA-β were not significantly different among the groups, but diastolic blood pressure was lower in the third tertile. Insulin, C-peptide, and HOMA-IR were higher in the lower birth weight tertile. After adjustment for confounding factors, birth weight was inversely related to diastolic blood pressure, insulin, C-peptide, and HOMA-IR. We conclude that low birth weight may predict the risk of the insulin resistance and its progression over age, and that adequate gestational nutrition is therefore necessary to prevent low birth weight.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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