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Anti-endothelial cell antibodies and antiphospholipid antibodies in Takayasu`s arteritis: correlations of their titers and isotype distributions with disease activity

 M.-C. Park  ;  Y.-B. Park  ;  S.Y. Jung  ;  K.H. Lee  ;  S.-K. Lee 
 CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.24(2 Suppl 41) : 10-16, 2006 
Journal Title
Issue Date
Adult ; Antibodies, Antiphospholipid/analysis ; Antibodies, Antiphospholipid/blood* ; Antibodies, Antiphospholipid/physiology ; Autoantibodies/analysis ; Autoantibodies/blood* ; Autoantibodies/physiology ; Blood Sedimentation ; Case-Control Studies ; Endothelium, Vascular/cytology ; Endothelium, Vascular/immunology ; Female ; Humans ; Immunoglobulin G/analysis ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin Isotypes/blood ; Immunoglobulin M/analysis ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; Male ; Middle Aged ; Severity of Illness Index ; Takayasu Arteritis/blood* ; Takayasu Arteritis/immunology* ; Takayasu Arteritis/physiopathology ; Umbilical Veins/cytology ; Umbilical Veins/immunology
OBJECTIVE: To investigate the prevalence of anti-endothelial cell antibodies (AECA) and antiphospholipid antibodies, and the correlations of their isotype distributions and titers with disease activity in patients with Takayasu's arteritis (TA). METHODS: Forty-seven patients with TA and 30 age- and sex-matched controls were studied. Blood samples were obtained from all patients and they were divided into either active or stable disease groups. Paired samples were available in 18 patients at both active and stable stage, respectively. AECA against human umbilical vein endothelial cells and antiphospholipid antibodies were measured. RESULTS: Forty-two (89.4%) TA patients had AECA, and positivity rates of IgM and IgG AECA were 83.0% and 68.1%, respectively, while those for controls were both 3.3%. The titers of IgM and IgG AECA in patients were significantly higher than those in controls. IgM AECA titers of the active group were significantly higher than those of the stable group, but IgG AECA titers were not. In 18 patients with paired samples, IgM AECA titers at active stage were significantly higher than those at stable stage, but IgG AECA titers were not different between stages. The changes of IgM AECA titers correlated well with those of ESR levels between stages. Antiphospholipid antibodies were detected in only 4 patients with TA, but not in controls. CONCLUSION: IgM AECA and IgG AECA were more prevalent and their titers were higher in patients with TA than in controls, and IgM AECA titers correlated well with the disease activity of TA. Antiphospholipid antibodies were not found significant.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Park, Min Chan(박민찬) ORCID logo https://orcid.org/0000-0003-1189-7637
Park, Yong Beom(박용범)
Lee, Kwang Hoon(이광훈)
Lee, Soo Kon(이수곤)
Jung, Sang Youn(정상윤)
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