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A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes

Authors
 Eun Seok Kang  ;  Hye Joo Kim  ;  Moonsuk Nam  ;  Chung Mo Nam  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Hyun Chul Lee 
Citation
 JOURNAL OF HUMAN GENETICS, Vol.51(7) : 629-633, 2006 
Journal Title
 JOURNAL OF HUMAN GENETICS 
ISSN
 1434-5161 
Issue Date
2006
MeSH
Adult ; Alleles ; Asian Continental Ancestry Group ; Calpain/genetics* ; Case-Control Studies ; Confidence Intervals ; Diabetes Mellitus, Type 2/genetics* ; Female ; Gene Frequency ; Genetic Variation ; Haplotypes* ; Humans ; Male ; Middle Aged ; Odds Ratio ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Risk Factors
Keywords
Calpain-10 ; Polymorphism ; Haplotype ; Type 2 diabetes ; CAPN10
Abstract
Genetic variations in the Calpain-10 gene, CAPN10, have been reported to be associated with the risk of type 2 diabetes mellitus (T2DM) in Mexican-Americans and Northern Europeans whereas these variations are not associated with T2DM in other populations. The aim of this study was to determine whether there is an association between specific CAPN10 diplotype (SNP-43, -19, and -63) and T2DM in the Korean population. Overall, 454 Korean patients with T2DM (male 230, female 224) and 236 non-diabetic controls (male 124, female 112) with no family history of diabetes were enrolled in this study. All the subjects were genotyped according to CAPN10 SNP-43, -19, and -63. The restriction fragment length polymorphism method was used for the three SNPs. There were eight estimated haplotype allelic variations. After adjusting for gender and age, the 111 haplotype was associated with a high risk of T2DM (P <0.0001). The 111/121 diplotype was associated with a high risk of T2DM (odds ratio =2.580, 95% confidence interval =1.602-4.155, P =0.001). The high-risk haplotype (112/121) in Mexican-Americans was not significant in our study population. In conclusion, we found that a novel 111/121 diplotype in Calpain-10 gene is associated with T2DM in the Korean population.
Full Text
http://www.nature.com/jhg/journal/v51/n7/full/jhg200695a.html
DOI
10.1007/s10038-006-0410-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108904
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