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Significance of small dense low-density lipoprotein as a risk factor for coronary artery disease and acute coronary syndrome

 Sung Woo Kwon  ;  Se-jung Yoon  ;  Tae Soo Kang  ;  Hyuck Moon Kwon  ;  Jeong-ho Kim  ;  Jihyuk Rhee  ;  Sung-ju Lee  ;  Jong-kwan Park  ;  Jae Yun Lim  ;  Young Won Yoon  ;  Bum Kee Hong 
 YONSEI MEDICAL JOURNAL, Vol.47(3) : 405-414, 2006 
Journal Title
Issue Date
Acute Disease ; Aged ; Biomarkers ; Coronary Artery Disease/blood* ; Coronary Artery Disease/epidemiology* ; Female ; Humans ; Lipoproteins, LDL/blood* ; Lipoproteins, LDL/chemistry ; Male ; Middle Aged ; Particle Size ; Predictive Value of Tests ; Risk Factors
Small dense LDL ; coronary artery disease
Small dense LDL (sd-LDL) has recently emerged as an important coronary artery disease (CAD) risk factor. This study was performed to investigate how LDL particle size is related to CAD and acute coronary syndrome (ACS). Blood samples were collected from 504 patients that underwent coronary angiography to evaluate chest pain. The LDL particle size of these samples was measured. The mean LDL particle size was smaller in patients with angiographically proven CAD than in the controls (26.41 ± 0.95 vs 26.73 ± 0.64 nm, p <0.001), and was negatively correlated with the Framingham risk score (r = -0.121, p = 0.007). Patients with more extensive CAD had smaller LDL particles. LDL particle size was also smaller in patients with acute coronary syndrome as compared to non-ACS patients (26.09 ± 1.42 vs 26.54 ± 0.63 nm, p = 0.011). These results suggest that sd-LDL is independently associated with the incidence and extent of CAD, and can be a risk factor for the development of ACS in the Korean population.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Rhee, Ji Hyuk(이지혁)
Lim, Jae Yun(임재윤)
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
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