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Insulin resistance is associated with hypertensive response to exercise in non-diabetic hypertensive patients

Authors
 Sungha Park  ;  Jaemin Shim  ;  Jin-Bae Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Jong-Won Ha  ;  Se-Joong Rim  ;  Yangsoo Jang  ;  Namsik Chung 
Citation
 DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.73(1) : 65-69, 2006 
Journal Title
 DIABETES RESEARCH AND CLINICAL PRACTICE 
ISSN
 0168-8227 
Issue Date
2006
MeSH
Adult ; Exercise/physiology* ; Female ; Humans ; Hypertension/physiopathology* ; Insulin Resistance/physiology* ; Male ; Middle Aged
Keywords
Insulin resistance ; Hypertension ; Hypertensive response to exercise
Abstract
AIM: Insulin resistance is associated with increased sympathetic activity and elevated angiotensin II which may contribute to the excessive increase in arterial blood pressure during exercise. In this study, we hypothesized that increased insulin resistance will be significantly associated with hypertensive response to exercise (HRE) in non-diabetic hypertensive patients. METHOD: Two hundred seventy-five hypertensive patients were included in this study. HOMA-IR index using serum fasting glucose and insulin was calculated for insulin resistance. There were 79 patients with hypertensive response (age 56.1+/-9.4 years) and 196 patients without hypertensive response (age 53.9+/-8.9 years). RESULTS: Insulin resistance, assessed by HOMA index, was significantly higher in hypertensive response group as compared to control (HOMA=2.60+/-1.54 versus 1.76+/-0.86, P<0.001). HOMA was an independent predictor of HRE when controlled for age, sex, BMI and baseline SBP (odds ratio=2.008, P<0.001). Also, HOMA was significantly correlated with the magnitude of SBP elevation controlled for age, sex, BMI and baseline SBP as well (beta=0.293, P<0.001). In conclusion, this study shows that insulin resistance is a significant determinant of hypertensive response to exercise. Further studies to determine the prognostic significance of this finding is warranted.
Full Text
http://www.sciencedirect.com/science/article/pii/S0168822705004419
DOI
10.1016/j.diabres.2005.11.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108890
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