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Regulator of G-protein Signaling (RGS) 단백질과 아편 신호 전달

Other Titles
 RGS Proteins and Opioid Signaling 
Authors
 김경선  ;  Pamela Pierce Palmer  ;  김기준 
Citation
 Korean Journal of Pain (대한통증학회지), Vol.19(1) : 8-16, 2006 
Journal Title
 Korean Journal of Pain  (대한통증학회지) 
ISSN
 2005-9159 
Issue Date
2006
Abstract
The regulators of the G protein signaling (RGS) proteins are responsible for the rapid acceleration of the GTPase-activity intrinsic to the heterotrimeric G protein alpha subunits. As GTPase-activating proteins (GAP), the RGS proteins negatively regulate the G-protein signals. Recently, the RGS proteins are known to be one of the important regulators of opioid signal transduction and the development of tolerance. The aim of this study was to review the recent discovery and understanding of the role of RGS proteins in opioid signaling and the development of tolerance. This information will be useful for medical personnel, particularly those involved in anesthesia and pain medicine, by helping them improve the effective use of opioids and develop new drugs that can prevent opioid tolerance.
Files in This Item:
T200600105.pdf Download
DOI
10.3344/kjp.2006.19.1.8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Jun(김기준) ORCID logo https://orcid.org/0000-0003-1950-7998
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108884
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