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Expression of tumor necrosis factor alpha and matrix metalloproteinase-9 in surgically induced necrotizing scleritis

DC Field Value Language
dc.contributor.author김응권-
dc.contributor.author서경률-
dc.contributor.author이준행-
dc.contributor.author이형근-
dc.date.accessioned2015-06-10T11:55:36Z-
dc.date.available2015-06-10T11:55:36Z-
dc.date.issued2006-
dc.identifier.issn0030-3747-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108872-
dc.description.abstractBACKGROUND: Surgically induced necrotizing scleritis is primarily managed with immunosuppressive regimens. Such treatments can alter inflammatory cytokines and products such as tumor necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-9 (MMP-9), which are an important proinflammatory cytokine and a tissue-degrading protease involved in necrosis of some ocular tissues. OBJECT: To evaluate TNF-alpha and MMP-9 in the tear or sclera of surgically induced necrotizing scleritis. METHODS: After tear collection from healthy and diseased eyes of 2 patients, immunoblot analysis using monoclonal antibody specific for human TNF-alpha and MMP-9 was performed. In another patient, scleral tissues were obtained during scleral allograft surgery, and the same immunoblot analysis was done. RESULTS: The level of TNF-alpha and MMP-9 was increased in tear fluid from patients compared to that of control volunteers and returned to the control level after treatment. The diseased sclera showed an increased expression of MMP-9 compared to that of the normal donor sclera. CONCLUSIONS: TNF-alpha and MMP-9 may suggest disease activity of surgically induced necrotizing scleritis and can be altered by proper immunosuppressive treatment.-
dc.description.statementOfResponsibilityopen-
dc.format.extent66~70-
dc.relation.isPartOfOPHTHALMIC RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers/metabolism-
dc.subject.MESHBlotting, Western-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMatrix Metalloproteinase 9/biosynthesis*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOphthalmologic Surgical Procedures/adverse effects*-
dc.subject.MESHPostoperative Complications-
dc.subject.MESHSclera/metabolism-
dc.subject.MESHScleritis/etiology-
dc.subject.MESHScleritis/metabolism*-
dc.subject.MESHScleritis/pathology-
dc.subject.MESHTears/metabolism-
dc.subject.MESHTumor Necrosis Factor-alpha/biosynthesis*-
dc.titleExpression of tumor necrosis factor alpha and matrix metalloproteinase-9 in surgically induced necrotizing scleritis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorKyoung Yul Seo-
dc.contributor.googleauthorHyung Keun Lee-
dc.contributor.googleauthorEung Kweon Kim-
dc.contributor.googleauthorJoon H. Lee-
dc.identifier.doi10.1159/000090010-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00831-
dc.contributor.localIdA01870-
dc.contributor.localIdA03180-
dc.contributor.localIdA03303-
dc.relation.journalcodeJ02428-
dc.identifier.eissn1423-0259-
dc.identifier.pmid16319517-
dc.identifier.urlhttp://www.karger.com/Article/FullText/90010-
dc.subject.keywordMMP-9-
dc.subject.keywordNecrotizing scleritis-
dc.subject.keywordTNF-α-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.alternativeNameSeo, Kyuong Yul-
dc.contributor.alternativeNameLee, Joon Haeng-
dc.contributor.alternativeNameLee, Hyung Keun-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.contributor.affiliatedAuthorSeo, Kyuong Yul-
dc.contributor.affiliatedAuthorLee, Joon Haeng-
dc.contributor.affiliatedAuthorLee, Hyung Keun-
dc.rights.accessRightsnot free-
dc.citation.volume38-
dc.citation.number2-
dc.citation.startPage66-
dc.citation.endPage70-
dc.identifier.bibliographicCitationOPHTHALMIC RESEARCH, Vol.38(2) : 66-70, 2006-
dc.identifier.rimsid49931-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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