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The changes of estrogen receptor-β variants expression in breast carcinogenesis: Decrease of estrogen receptor-β2 expression is the key event in breast cancer development

 Byeong-Woo Park  ;  Ki-Suk Kim  ;  Min-Kyu Heo  ;  Woo-Ick Yang  ;  Seung Il Kim  ;  Joo-Hang Kim  ;  Gwi Eon Kim  ;  Kyong Sik Lee 
 JOURNAL OF SURGICAL ONCOLOGY, Vol.93(6) : 504-510, 2006 
Journal Title
Issue Date
Breast/metabolism ; Breast Neoplasms/etiology* ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/genetics ; Estrogen Receptor beta/metabolism* ; Estrogen Receptor beta/physiology ; Female ; Humans ; Polymerase Chain Reaction ; Postmenopause/metabolism ; Premenopause/metabolism ; RNA Splicing/genetics ; RNA, Messenger/biosynthesis ; RNA, Neoplasm/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
estrogen receptor‐β ; variant ; breast cancer ; carcinogenesis ; RT‐PCR ; TP‐PCR
BACKGROUND AND OBJECTIVES: Although more than five variant forms of estrogen receptor-beta (ERbeta) have been identified, their role has not been identified. This study was carried out to investigate the changes of ERbeta variants in breast cancer development. METHODS: Using reverse transcription polymerase chain reaction (RT-PCR) and triple primer PCR (TP-PCR), the expression levels of ERbeta variants mRNA were measured in 66 paired normal and cancer tissues. The relative expression level of ERbeta variants were compared between normal and cancer tissues, and also compared according to various clinicopathological parameters. RESULTS: Among ERbeta variants, ERbeta2 and ERbeta5 consist of the major proportion of ERbeta expression both in normal and cancer tissues. The ERbeta and ERbeta2 expression levels decreased significantly in the cancers compared with corresponding normal tissues, particularly in ERalpha-expressing cancers. However, ERbeta5 expression level increased significantly in the cancers, especially in those of postmenopausal patients. The relative increase of ERbeta5 expression in cancer tissues was associated with favorable differentiation. CONCLUSIONS: Decrease of ERbeta2 is thought to be the key reason for the decrease in ERbeta expression in cancer tissues, and it is particularly associated with the development of ERalpha-expressing breast cancer.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Kim, Seung Il(김승일)
Kim, Joo Hang(김주항)
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
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