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Increased serum thymus and activation-regulated chemokine and cutaneous T cell-attracting chemokine levels in children with atopic dermatitis

Authors
 T. W. Song  ;  M. H. Sohn  ;  E. S. Kim  ;  K. W. Kim  ;  K.-E. Kim 
Citation
 CLINICAL AND EXPERIMENTAL ALLERGY, Vol.36(3) : 346-351, 2006 
Journal Title
 CLINICAL AND EXPERIMENTAL ALLERGY 
ISSN
 0954-7894 
Issue Date
2006
MeSH
Adolescent ; Aging/immunology ; Biomarkers/blood ; Chemokine CCL17 ; Chemokine CCL27 ; Chemokines, CC/blood* ; Child ; Child, Preschool ; Dermatitis, Atopic/immunology* ; Eczema/immunology ; Eosinophils/immunology ; Female ; Humans ; Immunoglobulin E/blood ; Infant ; Leukocyte Count ; Male ; Severity of Illness Index
Keywords
atopic dermatitis ; CTACK ; TARC
Abstract
BACKGROUND: Thymus and activation-regulated chemokine (TARC) and cutaneous T cell-attracting chemokine (CTACK) are responsible for the trafficking of T helper type 2 lymphocytes into sites of allergic inflammation. OBJECTIVE: We tested whether these cytokines are useful markers for childhood atopic dermatitis (AD), and evaluated age-related differences in the levels of these chemokines. METHODS: Serum TARC and CTACK levels, total serum IgE levels, total eosinophil counts, and specific IgE levels were measured in 401 children. The patients were characterized as having atopic eczema (n=157), non-atopic eczema (n=107), or as healthy control subjects (n=137). RESULTS: Both TARC and CTACK levels in children with AD were significantly higher than those in healthy control subjects. Serum TARC and CTACK levels significantly correlated with disease severity both in children with atopic eczema and in children with non-atopic eczema. Serum TARC levels in children with AD significantly correlated with their serum CTACK levels. Serum TARC and CTACK levels decreased in accordance with their ages. CONCLUSION: Serum TARC and CTACK levels might be useful markers for disease severity both in children with atopic eczema and with non-atopic eczema. Serum TARC and CTACK levels decreased in accordance with their ages.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2222.2006.02430.x/abstract
DOI
10.1111/j.1365-2222.2006.02430.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108749
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