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Post-interventional immunosuppressive treatment and vascular restenosis in Takayasu's arteritis

Authors
 M. C. Park  ;  S. W. Lee  ;  Y. B. Park  ;  S. K. Lee  ;  D. Choi  ;  W. H. Shim 
Citation
 RHEUMATOLOGY , Vol.45(5) : 600-605, 2006 
Journal Title
 RHEUMATOLOGY 
ISSN
 0080-2727 
Issue Date
2006
MeSH
Adolescent ; Adult ; Arterial Occlusive Diseases/diagnostic imaging ; Arterial Occlusive Diseases/etiology ; Arterial Occlusive Diseases/prevention & control* ; Arterial Occlusive Diseases/therapy ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Glucocorticoids/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use* ; Male ; Middle Aged ; Radiography ; Recurrence ; Retrospective Studies ; Takayasu Arteritis/complications ; Takayasu Arteritis/diagnostic imaging ; Takayasu Arteritis/therapy* ; Treatment Outcome ; Vascular Patency
Keywords
Takayasu's arteritis ; Vascular intervention ; Restenosis ; Immunosuppressive treatment
Abstract
OBJECTIVE: To investigate the outcome of vascular interventions and the effect of post-interventional immunosuppressive treatment on the occurrence of vascular restenosis in patients with Takayasu's arteritis (TA). METHODS: Forty-two patients with TA who had undergone vascular intervention and had serial angiographies before and after intervention were enrolled. The demographic and clinical data were collected at the time when the interventions were performed, and the intervention modalities and post-interventional medical treatments were evaluated. RESULTS: Sixty-three interventions were performed in 42 patients. Twenty (31.7%) interventions restenosed 24.0 +/- 21.9 months after intervention; the likelihood decreasing as time passed. Estimates of arterial patency after intervention were 90.1% at 1 yr, 75.5% at 2 yr, 68.4% at 3 yr, 61.6% at 5 yr and 49.3% at 10 yr. According to the log rank test, interventions that were performed during the stable stage of the disease (P = 0.039) and those that were followed by treatment with glucocorticoids and immunosuppressive agents (P = 0.044) were independent variables for the maintenance of arterial patency. Their hazard ratios were 0.30 and 0.41, respectively. CONCLUSION: Restenosis occurred in 31.7% of TA patients after intervention. A lower restenosis rate was observed when the vascular interventions were performed at the stable stage and when post-interventional immunosuppressive treatment was implemented.
Files in This Item:
T200600002.pdf Download
DOI
10.1093/rheumatology/kei245
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Min Chan(박민찬) ORCID logo https://orcid.org/0000-0003-1189-7637
Park, Yong Beom(박용범)
Shim, Won Heum(심원흠)
Lee, Soo Kon(이수곤)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108745
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