Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo.

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Authors: Juliana Idoyaga ; Cheolho Cheong ; Koji Suda ; Nao Suda ; Jae Y. Kim ; Haekyung Lee ; Chae Gyu Park ; Ralph M. Steinman

MeSH: Adoptive Transfer ; Animals ; Antibodies, Monoclonal/biosynthesis ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/metabolism* ; Antigen Presentation/genetics ; Antigen Presentation/immunology* ; Antigens, CD/immunology ; Antigens, CD/metabolism ; Antigens, CD/physiology* ; Antigens, Surface/immunology ; Antigens, Surface/metabolism ; Antigens, Surface/physiology ; Carrier Proteins/chemical synthesis ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Dendritic Cells/immunology* ; Dendritic Cells/metabolism* ; Epitopes, T-Lymphocyte/administration & dosage ; Epitopes, T-Lymphocyte/immunology ; Epitopes, T-Lymphocyte/metabolism ; Histocompatibility Antigens Class I/metabolism* ; Histocompatibility Antigens Class II/metabolism* ; Lectins, C-Type/immunology ; Lectins, C-Type/metabolism ; Lectins, C-Type/physiology* ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Mannose-Binding Lectins/immunology ; Mannose-Binding Lectins/metabolism ; Mannose-Binding Lectins/physiology* ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Ovalbumin/administration & dosage ; Ovalbumin/immunology ; Ovalbumin/metabolism ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Spleen/cytology ; Spleen/immunology ; Spleen/metabolism

Keywords: Adoptive Transfer ; Animals ; Antibodies, Monoclonal/biosynthesis ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/metabolism* ; Antigen Presentation/genetics ; Antigen Presentation/immunology* ; Antigens, CD/immunology ; Antigens, CD/metabolism ; Antigens, CD/physiology* ; Antigens, Surface/immunology ; Antigens, Surface/metabolism ; Antigens, Surface/physiology ; Carrier Proteins/chemical synthesis ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Dendritic Cells/immunology* ; Dendritic Cells/metabolism* ; Epitopes, T-Lymphocyte/administration & dosage ; Epitopes, T-Lymphocyte/immunology ; Epitopes, T-Lymphocyte/metabolism ; Histocompatibility Antigens Class I/metabolism* ; Histocompatibility Antigens Class II/metabolism* ; Lectins, C-Type/immunology ; Lectins, C-Type/metabolism ; Lectins, C-Type/physiology* ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Mannose-Binding Lectins/immunology ; Mannose-Binding Lectins/metabolism ; Mannose-Binding Lectins/physiology* ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Ovalbumin/administration & dosage ; Ovalbumin/immunology ; Ovalbumin/metabolism ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Spleen/cytology ; Spleen/immunology ; Spleen/metabolism