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Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons

DC FieldValueLanguage
dc.contributor.author정호성-
dc.date.accessioned2015-05-19T17:42:29Z-
dc.date.available2015-05-19T17:42:29Z-
dc.date.issued2008-
dc.identifier.issn0022-3042-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108661-
dc.description.abstractIt has previously been observed that expression of chemokine monocyte chemoattractant protein-1 (MCP-1/CC chemokine ligand 2 (CCL2)) and its receptor CC chemokine receptor 2 (CCR2) is up-regulated by dorsal root ganglion (DRG) neurons in association with rodent models of neuropathic pain. MCP-1 increases the excitability of nociceptive neurons after a peripheral nerve injury, while disruption of MCP-1/CCR2 signaling blocks the development of neuropathic pain, suggesting MCP-1 signaling is responsible for heightened pain sensitivity. To define the mechanisms of MCP-1 signaling in DRG, we studied intracellular processing, release, and receptor-mediated signaling of MCP-1 in DRG neurons. We found that in a focal demyelination model of neuropathic pain both MCP-1 and CCR2 were up-regulated by the same neurons including transient receptor potential vanilloid receptor subtype 1 (TRPV1) expressing nociceptors. MCP-1 expressed by DRG neurons was packaged into large dense-core vesicles whose release could be induced from the soma by depolarization in a Ca2+-dependent manner. Activation of CCR2 by MCP-1 could sensitize nociceptors via transactivation of transient receptor potential channels. Our results suggest that MCP-1 and CCR2, up-regulated by sensory neurons following peripheral nerve injury, might participate in neural signal processing which contributes to sustained excitability of primary afferent neurons.-
dc.description.statementOfResponsibilityopen-
dc.format.extent254~263-
dc.relation.isPartOfJOURNAL OF NEUROCHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMonocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학)-
dc.contributor.googleauthorHosung Jung-
dc.contributor.googleauthorPeter T. Toth-
dc.contributor.googleauthorFletcher A. White-
dc.contributor.googleauthorRichard J. Miller-
dc.identifier.doi10.1111/j.1471-4159.2007.04969.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03786-
dc.relation.journalcodeJ01620-
dc.identifier.eissn1471-4159-
dc.identifier.pmidChemokine; Neurotransmitter; DRG; Neuropathic pain; TRPV1; TRPA1-
dc.subject.keywordChemokine-
dc.subject.keywordNeurotransmitter-
dc.subject.keywordDRG-
dc.subject.keywordNeuropathic pain-
dc.subject.keywordTRPV1-
dc.subject.keywordTRPA1-
dc.contributor.alternativeNameJung, Ho Sung-
dc.contributor.affiliatedAuthorJung, Ho Sung-
dc.rights.accessRightsfree-
dc.citation.volume104-
dc.citation.number1-
dc.citation.startPage254-
dc.citation.endPage263-
dc.identifier.bibliographicCitationJOURNAL OF NEUROCHEMISTRY, Vol.104(1) : 254-263, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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