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Combined surgery and postoperative radiotherapy for oropharyngeal squamous cell carcinoma in Korea: analysis of 110 cases

DC Field Value Language
dc.contributor.author유대현-
dc.contributor.author최은창-
dc.date.accessioned2015-05-19T17:42:16Z-
dc.date.available2015-05-19T17:42:16Z-
dc.date.issued2008-
dc.identifier.issn0901-5027-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108656-
dc.description.abstractThe treatment of oropharyngeal squamous cell carcinoma (OSCC) remains controversial. This study reviews the authors' experience of treating OSCC, evaluates the oncologic outcome and assesses the factors affecting local/regional recurrence. A retrospective analysis of 110 consecutive OSCC patients treated primarily by surgery and/or postoperative radiotherapy was carried out. 82% of patients had advanced disease (stage III or IV). The 5-year overall survival and disease specific survival rates (DSSR) were 58% and 65%, respectively. The DSSR of the soft palate or posterior pharyngeal wall, tonsillar area, and base of tongue were 80%, 62%, and 51%, respectively (P<0.05). The 5-year DSSR according to the American Joint Committee on Cancer stages was 94% for early stage and 56% for advanced stage (P<0.05). The overall recurrence rate was 38% (42 patients). The most frequent site of recurrence was the neck (46%). Only 14% of patients with recurrences were treated successfully. Positive resection margins and the presence of pathologic lymph nodes influenced the recurrence at the primary lesion and in the neck, respectively, in a statistically significant manner. Surgery and postoperative radiotherapy provided a superior outcome in patients with advanced OSCC. A randomized study is required to assess the oncologic and functional superiority of surgery or chemoradiation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1099~1105-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Squamous Cell/radiotherapy-
dc.subject.MESHCarcinoma, Squamous Cell/secondary-
dc.subject.MESHCarcinoma, Squamous Cell/surgery*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHLymphatic Metastasis/pathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeck/pathology-
dc.subject.MESHNeck Dissection-
dc.subject.MESHNeoadjuvant Therapy*-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHOropharyngeal Neoplasms/radiotherapy-
dc.subject.MESHOropharyngeal Neoplasms/surgery*-
dc.subject.MESHPalate, Soft/radiation effects-
dc.subject.MESHPalate, Soft/surgery-
dc.subject.MESHRadiotherapy Dosage-
dc.subject.MESHRadiotherapy, Adjuvant-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSalvage Therapy-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTongue Neoplasms/radiotherapy-
dc.subject.MESHTongue Neoplasms/surgery-
dc.subject.MESHTonsillar Neoplasms/radiotherapy-
dc.subject.MESHTonsillar Neoplasms/surgery-
dc.subject.MESHTreatment Outcome-
dc.titleCombined surgery and postoperative radiotherapy for oropharyngeal squamous cell carcinoma in Korea: analysis of 110 cases-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorY. C. Lim-
dc.contributor.googleauthorH. J. Hong-
dc.contributor.googleauthorS. J. Baek-
dc.contributor.googleauthorJ. H. Park-
dc.contributor.googleauthorG. E. Kim-
dc.contributor.googleauthorC. G. Lee-
dc.contributor.googleauthorD. H. Lew-
dc.contributor.googleauthorW. J. Lee-
dc.contributor.googleauthorE. C. Choi-
dc.identifier.doi10.1016/j.ijom.2008.07.002-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02459-
dc.contributor.localIdA04161-
dc.relation.journalcodeJ01143-
dc.identifier.eissn1399-0020-
dc.identifier.pmid18722091-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0901502708002816-
dc.subject.keywordoropharyx-
dc.subject.keywordsquamous cell carcinoma-
dc.subject.keywordtreatment-
dc.subject.keywordsurgery-
dc.contributor.alternativeNameLew, Dae Hyun-
dc.contributor.alternativeNameChoi, Eun Chang-
dc.contributor.affiliatedAuthorLew, Dae Hyun-
dc.contributor.affiliatedAuthorChoi, Eun Chang-
dc.rights.accessRightsnot free-
dc.citation.volume37-
dc.citation.number12-
dc.citation.startPage1099-
dc.citation.endPage1105-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol.37(12) : 1099-1105, 2008-
dc.identifier.rimsid37159-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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