Cited 108 times in
Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2015-05-19T17:42:00Z | - |
dc.date.available | 2015-05-19T17:42:00Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1462-5814 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108647 | - |
dc.description.abstract | Mycobacterium abscessus (Mab) is an emerging and rapidly growing non-tuberculous mycobacterium (NTM). Compared with M. tuberculosis, which is responsible for tuberculosis, much less is known about NTM-induced innate immune mechanisms. Here we investigated the involvement of pattern-recognition receptors and associated signalling in Mab-mediated innate immune responses. Mab activated the extracellular signal-regulated kinase (ERK)1/2 and p38 mitogen-activated protein kinases (MAPKs), and induced the secretion of tumour necrosis factor-alpha, interleukin (IL)-6 and IL-12p40 in murine macrophages via Toll-like receptor (TLR) 2. Notably, the activation of ERK1/2, but not p38, was crucial for Mab-induced pro-inflammatory cytokine production. The ITAM-like motif of dectin-1 critically contributed to Mab internalization and cytokine secretion by macrophages. In addition, dectin-1, in cooperation with TLR2, was required for the efficient phagocytosis of Mab, ERK1/2 activation and pro-inflammatory cytokine secretion. Co-immunoprecipitation and confocal analysis showed the physical interaction and colocalization of dectin-1 with TLR2 following Mab stimulation. Moreover, dectin-1-induced Syk activation was essential for the production of inflammatory cytokines and the release of reactive oxygen species by Mab-infected macrophages. Collectively, these data demonstrate that Mab actively internalizes into and robustly activates innate immune responses in macrophages through a physical and functional interaction between TLR2 and dectin-1. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1608~1621 | - |
dc.relation.isPartOf | CELLULAR MICROBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Dong-Min Shin | - |
dc.contributor.googleauthor | Chul-Su Yang | - |
dc.contributor.googleauthor | Jae-Min Yuk | - |
dc.contributor.googleauthor | Ji-Yeon Lee | - |
dc.contributor.googleauthor | Ki Hye Kim | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Kazuhiko Takahara | - |
dc.contributor.googleauthor | Sung Joong Lee | - |
dc.contributor.googleauthor | Eun-Kyeong Jo | - |
dc.identifier.doi | 10.1111/j.1462-5822.2008.01151.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J00499 | - |
dc.identifier.eissn | 1462-5822 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1462-5822.2008.01151.x/abstract | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1608 | - |
dc.citation.endPage | 1621 | - |
dc.identifier.bibliographicCitation | CELLULAR MICROBIOLOGY, Vol.10(8) : 1608-1621, 2008 | - |
dc.identifier.rimsid | 37152 | - |
dc.type.rims | ART | - |
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