Cited 30 times in
In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria.
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2015-05-19T17:41:54Z | - |
dc.date.available | 2015-05-19T17:41:54Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0924-8579 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108644 | - |
dc.description.abstract | Sulfometuron methyl (SM) is an inhibitor of acetohydroxyacid synthase (AHAS), the first common enzyme in the branched-chain amino acid biosynthetic pathway, and shows activity against Mycobacterium tuberculosis both in vitro and in vivo. To develop AHAS inhibitor derivatives with more potent activity, 100 sulfonylurea analogues were screened for antimycobacterial activity against M. tuberculosis and non-tuberculous mycobacteria (NTM), and then evaluated for intracellular activity using mouse macrophages. Three new compounds with antimycobacterial activity comparable with that of SM were identified. These compounds exhibit significant activity against intracellular M. tuberculosis (including the drug-resistant M. tuberculosis strains), and NTM Mycobacterium abscessus and Mycobacterium kansasii, respectively. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 567~571 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetolactate Synthase/antagonists & inhibitors* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Bacterial Agents/chemistry | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology* | - |
dc.subject.MESH | Antitubercular Agents/chemistry | - |
dc.subject.MESH | Antitubercular Agents/pharmacology* | - |
dc.subject.MESH | Bone Marrow Cells/drug effects | - |
dc.subject.MESH | Enzyme Inhibitors/chemistry | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology* | - |
dc.subject.MESH | Macrophages/drug effects | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Mycobacterium/drug effects* | - |
dc.subject.MESH | Mycobacterium tuberculosis/drug effects* | - |
dc.subject.MESH | Structure-Activity Relationship | - |
dc.subject.MESH | Sulfonylurea Compounds/pharmacology | - |
dc.title | In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Hosung Sohn | - |
dc.contributor.googleauthor | Kil-Soo Lee | - |
dc.contributor.googleauthor | Young-Kwan Ko | - |
dc.contributor.googleauthor | Jae-Wook Ryu | - |
dc.contributor.googleauthor | Jae-Choon Woo | - |
dc.contributor.googleauthor | Dong-Wan Koo | - |
dc.contributor.googleauthor | Sung-Jae Shin | - |
dc.contributor.googleauthor | Se-Jin Ahn | - |
dc.contributor.googleauthor | A-Rum Shin | - |
dc.contributor.googleauthor | Chang-Hwa Song | - |
dc.contributor.googleauthor | Eun-Kyeong Jo | - |
dc.contributor.googleauthor | Jeong-Kyu Park | - |
dc.contributor.googleauthor | Hwa-Jung Kim | - |
dc.identifier.doi | 10.1016/j.ijantimicag.2008.01.016 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J01088 | - |
dc.identifier.eissn | 1872-7913 | - |
dc.identifier.pmid | 18337064 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0924857908000460 | - |
dc.subject.keyword | Mycobacterium tuberculosis | - |
dc.subject.keyword | Antimycobacterial drug | - |
dc.subject.keyword | Acetohydroxyacid synthase inhibitor | - |
dc.subject.keyword | Non-tuberculous mycobacteria | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 31 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 567 | - |
dc.citation.endPage | 571 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, Vol.31(6) : 567-571, 2008 | - |
dc.identifier.rimsid | 37149 | - |
dc.type.rims | ART | - |
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