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Cited 23 times in

In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Affects the Development of Reproductive System in Mouse

DC Field Value Language
dc.contributor.author고혜경-
dc.contributor.author김매화-
dc.contributor.author한상원-
dc.contributor.author홍창희-
dc.date.accessioned2015-05-19T17:41:11Z-
dc.date.available2015-05-19T17:41:11Z-
dc.date.issued2008-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108621-
dc.description.abstractPURPOSE: Exposure of male reproductive organs to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) has been reported to cause developmental changes. In this study, we evaluated the effects of in utero TCDD exposure on male reproductive development. MATERIALS AND METHODS: Pregnant C57BL/6 mice were administered a single intraperitoneal injection of TCDD (1microgram/kg) on gestation day (GD) 15. The offspring were examined in the immature stage on postnatal day (PND) 30 and in the mature stage on PND 60. The testes were examined for histological changes, androgen receptor (AR), proliferating cell nuclear antigen (PCNA) and apoptosis following the measurement of morphological changes. RESULTS: Anogenital distance (AGD) and testis weights were reduced by TCDD exposure both on PND 30 and PND 60 while body weights and length of male offspring were not affected by TCDD. The regular sperm developmental stage was impaired with TCDD treatment on PND 30. However, no difference was found between the control group and TCDD groups on PND 60. Simultaneously, the expression of AR was also reduced on PND 30, while it was increased on PND 60 compared with the control group. The expression of PCNA was decreased whereas apoptosis was not affected by TCDD both on PND 30 and PND 60. CONCLUSION: These results suggest that in utero exposure to TCDD influences the development of testes by inhibiting the expression of AR and PCNA. Moreover, the adverse effects of TCDD on male offspring reduced over time-
dc.description.statementOfResponsibilityopen-
dc.format.extent843~850-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/drug effects-
dc.subject.MESHCell Proliferation-
dc.subject.MESHEmbryonic Development/drug effects*-
dc.subject.MESHEnvironmental Pollutants/toxicity*-
dc.subject.MESHFemale-
dc.subject.MESHMale-
dc.subject.MESHMaternal Exposure*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHOrgan Size/drug effects-
dc.subject.MESHPolychlorinated Dibenzodioxins/toxicity*-
dc.subject.MESHPregnancy-
dc.subject.MESHReceptors, Androgen/metabolism-
dc.subject.MESHTestis/drug effects*-
dc.subject.MESHTestis/embryology-
dc.subject.MESHTestis/pathology-
dc.titleIn Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Affects the Development of Reproductive System in Mouse-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorMei Hua Jin-
dc.contributor.googleauthorHae Kyung Ko-
dc.contributor.googleauthorChang Hee Hong-
dc.contributor.googleauthorSang Won Han-
dc.identifier.doi10.3349/ymj.2008.49.5.843-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04285-
dc.contributor.localIdA00153-
dc.contributor.localIdA00421-
dc.contributor.localIdA04447-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid18972606-
dc.subject.keyword2,3,7,8-Tetrachlorodibenzo-p-Dioxin-
dc.subject.keywordandrogen receptor-
dc.subject.keywordtestis-
dc.subject.keywordapoptosis-
dc.subject.keywordproliferation-
dc.contributor.alternativeNameKo, Hae Kyung-
dc.contributor.alternativeNameJin, Mei Hua-
dc.contributor.alternativeNameHan, Sang Won-
dc.contributor.alternativeNameHong, Chang Hee-
dc.contributor.affiliatedAuthorHan, Sang Won-
dc.contributor.affiliatedAuthorKo, Hae Kyung-
dc.contributor.affiliatedAuthorJin, Mei Hua-
dc.contributor.affiliatedAuthorHong, Chang Hee-
dc.rights.accessRightsfree-
dc.citation.volume49-
dc.citation.number5-
dc.citation.startPage843-
dc.citation.endPage850-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.49(5) : 843-850, 2008-
dc.identifier.rimsid37135-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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