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Anti-proliferative effect of licochalcone A on vascular smooth muscle cells
DC Field | Value | Language |
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dc.contributor.author | 차정헌 | - |
dc.date.accessioned | 2015-05-19T17:41:05Z | - |
dc.date.available | 2015-05-19T17:41:05Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108618 | - |
dc.description.abstract | Licochalcone A, a flavonoid found in licorice root (Glycyrrhiza glabra), is known for its anti-microbial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we investigated whether licochalcone A inhibits rat vascular smooth muscle cell (rVSMC) proliferation. Our data indicate that 5 microM licochalcone A inhibited platelet-derived growth factor (PDGF)-induced rVSMC proliferation, possibly through its ability to block the progression of the cell cycle from G1 to S phase. In addition, 5 microM licochalcone A significantly inhibited the PDGF-induced expression of cyclin A, cyclin D1, CDK2, and CDK4, and the phosphorylation of Rb. Licochalcone A also reversed the decrease in p27(kip1) expression reduced by PDGF. Finally, licochalcone A inhibited the PDGF-induced activation of extracellular signal-regulated kinase (ERK)1/2. Together, these data provide the first evidence that licochalcone A can regulate rVSMC proliferation and suggest that licochalcone A inhibits the proliferation of rVSMCs by suppressing the PDGF-induced activation of the ERK1/2 pathway and Rb phosphorylation, resulting in cell cycle arrest | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1996~2000 | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Cycle/drug effects | - |
dc.subject.MESH | Cell Cycle Proteins/biosynthesis | - |
dc.subject.MESH | Cell Proliferation/drug effects* | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Chalcones/isolation & purification | - |
dc.subject.MESH | Chalcones/pharmacology* | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/metabolism | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Glycyrrhiza/chemistry | - |
dc.subject.MESH | Glycyrrhiza/classification | - |
dc.subject.MESH | Muscle, Smooth, Vascular/cytology | - |
dc.subject.MESH | Muscle, Smooth, Vascular/drug effects* | - |
dc.subject.MESH | Muscle, Smooth, Vascular/metabolism | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Platelet-Derived Growth Factor/pharmacology | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | Anti-proliferative effect of licochalcone A on vascular smooth muscle cells | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Jin-Hee PARK | - |
dc.contributor.googleauthor | Hyun Joung LIM | - |
dc.contributor.googleauthor | Kuy-Sook LEE | - |
dc.contributor.googleauthor | Seahyoung LEE | - |
dc.contributor.googleauthor | Hyun-Jeong KWAK | - |
dc.contributor.googleauthor | Jeong-Heon CHA | - |
dc.contributor.googleauthor | Hyun-Young PARK | - |
dc.identifier.doi | 18981562 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04007 | - |
dc.relation.journalcode | J00300 | - |
dc.identifier.eissn | 1347-5215 | - |
dc.identifier.pmid | 18981562 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Blotting, Western | - |
dc.subject.keyword | Cell Cycle/drug effects | - |
dc.subject.keyword | Cell Cycle Proteins/biosynthesis | - |
dc.subject.keyword | Cell Proliferation/drug effects* | - |
dc.subject.keyword | Cell Survival/drug effects | - |
dc.subject.keyword | Cells, Cultured | - |
dc.subject.keyword | Chalcones/isolation & purification | - |
dc.subject.keyword | Chalcones/pharmacology* | - |
dc.subject.keyword | Extracellular Signal-Regulated MAP Kinases/metabolism | - |
dc.subject.keyword | Flow Cytometry | - |
dc.subject.keyword | Glycyrrhiza/chemistry | - |
dc.subject.keyword | Glycyrrhiza/classification | - |
dc.subject.keyword | Muscle, Smooth, Vascular/cytology | - |
dc.subject.keyword | Muscle, Smooth, Vascular/drug effects* | - |
dc.subject.keyword | Muscle, Smooth, Vascular/metabolism | - |
dc.subject.keyword | Phosphorylation | - |
dc.subject.keyword | Platelet-Derived Growth Factor/pharmacology | - |
dc.subject.keyword | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.keyword | Rats | - |
dc.subject.keyword | Rats, Sprague-Dawley | - |
dc.contributor.alternativeName | Cha, Jung Heon | - |
dc.contributor.affiliatedAuthor | Cha, Jung Heon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 31 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1996 | - |
dc.citation.endPage | 2000 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, Vol.31(11) : 1996-2000, 2008 | - |
dc.identifier.rimsid | 37133 | - |
dc.type.rims | ART | - |
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