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당뇨병성 신증의 조기 예측 인자로서의 혈중 cystatin C 및 β2-microglobulin의 유용성

Other Titles
 Effectiveness of Serum Cystatin C and β2-microglobulin as early Predictive Markers of Diabetic Nephropathy 
Authors
 채현욱  ;  신재일  ;  김범석  ;  김호성  ;  김덕희 
Citation
 Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지), Vol.13(2) : 177-183, 2008 
Journal Title
 Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지) 
ISSN
 1226-2242 
Issue Date
2008
Keywords
Diabetic nephropathy ; Cystatin C ; β2-microglobulin ; Creatinine
Abstract
Purpose : Early detection of diabetic nephropathy is very important for prevention of renal failure. Determination of microalbuminuria has been suggested as an early predictor of diabetic nephropathy, but it is tend to be erroneous and inaccurate, especially in childhood. The aim of this study is to show clinical values of serum cystatin C and β2-microglobulin in the assessment of renal function in diabetic children and adolescents. Methods : Ninety four type 1 and 2 diabetic patients with normoalbuminuria (n=78), microalbuminuria (n= 15) and macroalbuminuria (n=1) were enrolled. Serum concentration of cystatin C, β2-microglobulin, creatinine, urinary microalbumin levels and creatinine clearances were determined. Results : In patients with microalbuminuria, serum concentration of cystatin C was increased significantly in comparison to patients with normoalbuminuria (P<0.05), while no differences were observed for β2- microglobulin levels. Serum creatinine concentrations were not different between both groups. Serum concentration of cystatin C was positively correlated with serum β2-microglobulin and serum creatinine. The serum concentration of β2 -microglobulin was not correlated with the decrease of renal function significantly. Conclusion : Serum cystatin C is a useful endogenous marker in assessment of renal function in pediatric diabetic patients.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hee(김덕희)
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Chae, Hyun Wook(채현욱) ORCID logo https://orcid.org/0000-0001-5016-8539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108616
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