The liver is the most common site of distant metastasis of colorectal cancer, and surgical resection is the only therapy that offers the possibility of a cure. However, only 10~20% patients with colorectal liver metastases are candidates for surgical resection upon initial presentation. For patients with unresectable liver metastasis, systemic chemotherapy or hepatic arterial chemoembolization, radiofrequency thermal ablation and immunotherapy are used as alternative therapies. In general, colorectal liver metastasis is an absolute contraindication for liver transplantation. Here, we present the case of a patient who has survived cancer-free for more than 2 years after liver transplantation as rescue therapy for acute hepatic failure after chemoembolization for liver metastasis from colon cancer. This case demonstrates that liver transplantation may be a curative modality in selected patients with hepatic failure and colorectal liver metastasis.