Cited 9 times in
Collagen XVIII and corneal reinnervation following keratectomy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김태임 | - |
dc.date.accessioned | 2015-05-19T17:37:54Z | - |
dc.date.available | 2015-05-19T17:37:54Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108516 | - |
dc.description.abstract | The significance of collagen XVIII in the regulation of corneal reinnervation remains largely unknown. We used whole-mount immunoconfocal microscopy to localize collagen XVIII to the nerve basement membrane of wild-type (WT) mouse corneas. Transmission electron microscopy showed corneal nerve disorganization in collagen XVIII knockout mice (col18a1(-/-)). Antibody 2H3-specific neurofilament colocalized with collagens XVIII and IV and laminin-2 in WT mouse corneas, but did not colocalize with collagen IV and laminin-2 in col18a1(-/-) mouse corneas. Following keratectomy, col18a1(-/-) mice displayed decreased corneal neurite extension compared to WT mice. Our data indicate that collagen XVIII may play an important role in corneal reinnervation after wounding. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3674~3680 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Collagen Type IV/genetics | - |
dc.subject.MESH | Collagen Type IV/physiology | - |
dc.subject.MESH | Collagen Type XVIII/genetics | - |
dc.subject.MESH | Collagen Type XVIII/physiology* | - |
dc.subject.MESH | Cornea/innervation* | - |
dc.subject.MESH | Cornea/physiology | - |
dc.subject.MESH | Corneal Injuries* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Mutant Strains | - |
dc.subject.MESH | Microscopy, Electron, Transmission | - |
dc.subject.MESH | Nerve Regeneration*/genetics | - |
dc.subject.MESH | Neurites/metabolism | - |
dc.subject.MESH | Neurites/physiology | - |
dc.subject.MESH | Peripheral Nerves/metabolism | - |
dc.subject.MESH | Peripheral Nerves/physiology* | - |
dc.subject.MESH | Peripheral Nerves/ultrastructure | - |
dc.subject.MESH | Wound Healing*/genetics | - |
dc.title | Collagen XVIII and corneal reinnervation following keratectomy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Tohru Sakimoto | - |
dc.contributor.googleauthor | Tae-im Kim | - |
dc.contributor.googleauthor | David Ellenberg | - |
dc.contributor.googleauthor | Naomi Fukai | - |
dc.contributor.googleauthor | Sandeep Jain | - |
dc.contributor.googleauthor | Dimitri T. Azar | - |
dc.contributor.googleauthor | Jin-Hong Chang | - |
dc.identifier.doi | 10.1016/j.febslet.2008.09.052 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01080 | - |
dc.relation.journalcode | J00890 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.identifier.pmid | 18840438 | - |
dc.subject.keyword | extracellular matrix | - |
dc.subject.keyword | collagen XVIII | - |
dc.contributor.alternativeName | Kim, Tae Im | - |
dc.contributor.affiliatedAuthor | Kim, Tae Im | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 582 | - |
dc.citation.number | 25-26 | - |
dc.citation.startPage | 3674 | - |
dc.citation.endPage | 3680 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, Vol.582(25-26) : 3674-3680, 2008 | - |
dc.identifier.rimsid | 37048 | - |
dc.type.rims | ART | - |
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