0 417

Cited 21 times in

Prevalence and genotype distribution of hepatitis C virus among apparently healthy individuals in Mongolia: a population-based nationwide study.

Authors
 Oidov Baatarkhuu  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Pagvajav Nymadawa  ;  Yagaanbuyant Dahgwahdorj  ;  Manaljav Shagdarsuren  ;  Jun Yong Park  ;  Jong Won Choi  ;  Janchiv Oyunbileg  ;  Tsendsuren Oyunsuren  ;  Kwang Hyub Han 
Citation
 LIVER INTERNATIONAL, Vol.28(10) : 1389-1395, 2008 
Journal Title
LIVER INTERNATIONAL
ISSN
 1478-3223 
Issue Date
2008
MeSH
Age Factors ; Genotype ; Hepacivirus/genetics* ; Hepatitis C/epidemiology* ; Hepatitis C/genetics ; Humans ; Mongolia/epidemiology ; Prevalence ; Reverse Transcriptase Polymerase Chain Reaction ; Risk Factors
Keywords
genotype ; HCV RNA ; hepatitis C virus ; Mongolia ; prevalence
Abstract
BACKGROUND AND AIMS: Hepatitis C virus (HCV) is one of the major causes of liver cirrhosis and hepatocellular carcinoma (HCC) in Mongolia. However, there are no data concerning nationwide prevalence of HCV infection in Mongolia. We intended to investigate the population-based prevalence of HCV infection and genotype distribution among 1512 apparently healthy individuals in this country.

METHODS: Between April 2003 and December 2005, sera from 1512 residents of Ulaanbaatar and 12 provinces were collected by two-stage cluster random sampling, and anti-HCV was tested. Anti-HCV-positive samples were tested for HCV RNA by reverse transcription polymerase chain reaction, and HCV genotype was determined.

RESULTS: The mean age of the subjects was 46.2+/-17.8 years, and 812 (53.7%) were male. Overall, the prevalence of anti-HCV was 15.6% (236/1512) and HCV RNA was detected in 167 subjects (11.0%), with the most common genotype being 1b (165/167, 98.8%). When the HCV RNA-positive subjects were categorized by decade of age, the prevalence in each age group was as follows: 2.5% in subjects /=61 years of age. The seroprevalence of anti-HCV in a risk group, nurses, was not significantly different from the general population in each decade of age (P>0.05).

CONCLUSIONS: Approximately 11.0% of apparently healthy population had detectable HCV RNA in Mongolia, and the predominant genotype of HCV was 1b. Preventive and therapeutic strategies for chronic hepatitis C are urgently warranted in this HCV-endemic area.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2008.01820.x/abstract
DOI
10.1111/j.1478-3231.2008.01820.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108463
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links