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Agmatine이 GABA(A) 수용체 길항제로 유도한 촉각이질통에 미치는 효과

Other Titles
 Effects of Agmatine on GABA(A) Receptor Antagonist-induced Tactile Allodynia 
Authors
 이윤우  ;  이시카와 토시쪼 
Citation
 Korean Journal of Pain (대한통증학회지), Vol.21(3) : 173-178, 2008 
Journal Title
Korean Journal of Pain (대한통증학회지)
ISSN
 2005-9159 
Issue Date
2008
Keywords
agmatine ; GABAA receptor antagonist ; tactile allodynia
Abstract
Background
The intrathecal (IT) GABAA receptor antagonist, bicuculline (BIC), results in tactile allodynia (TA) through disinhibition in the spinal cord. Such disinhibition is considered to be an important mechanism for neuropathic pain. Agmatine, an endogenous polyamine, has a neuro-protective effect in the central nervous system. We investigated the analgesic effects and mechanisms of agmatine action on BIC-induced TA.

Methods
Male Sprague-Dawley rats, weighting 250-300 g, were subjected to implantations of PE-10 into the lumbar subarachnoid space for IT drug injection. Five days after surgery, either 10 µl of normal saline (NS) or agmatine (30 µg or 10 µg) in 10 µl NS were injected 10 min prior to BIC (10 µg) or NMDA (5 µg). We assessed the degree of TA (graded 0: no response, 1: mild response, 2: moderate response, 3: strong response) every 5 min for 30 min. Areas under curves and degree of TA were expressed as mean ± SEM. Results were analyzed using one-way ANOVA followed by a Tukey test for multiple comparisons. P < 0.05 was considered significant.

Results
IT BIC-induced strong TA reached its peak and plateaued between 10 to 15 min. IT NS-NMDA induced mild transient TA for up to 15 min. Preemptive IT AG attenuated IT BIC-induced TA dose dependently and preemptive IT AG10 completely abolished the IT NMDA-induced TA.

Conclusions
Preemptive IT AG attenuated the IT BIC-induced TA through inhibitory actions on postsynaptic NMDA receptor activation. AG might be a viable therapeutic option in the treatment of neuropathic pain.
Files in This Item:
T200805642.pdf Download
DOI
10.3344/kjp.2008.21.3.173
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Youn Woo(이윤우)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108440
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