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염색체성 AmpC β-lactamase 생성 Enterobacteriaceae 균종에서의 CTX-M형 extended-spectrum β-lactamase 검출과 분자유전학적 특성 규명
DC Field | Value | Language |
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dc.contributor.author | 김창기 | - |
dc.contributor.author | 염종화 | - |
dc.contributor.author | 용동은 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 정석훈 | - |
dc.contributor.author | 정윤섭 | - |
dc.date.accessioned | 2015-05-19T17:33:02Z | - |
dc.date.available | 2015-05-19T17:33:02Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1229-0025 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108357 | - |
dc.description.abstract | Background: Clinical isolates of AmpC β-lactamase producing Enterobacteriaceae were evaluated to determine the prevalence of CTX-M extended-spectrum β-lactamases (ESBLs) and their genetic environments. Methods: A total of 250 non-duplicate isolates of Eneterobacter aerogenes, E. cloacae, Citrobacter freundii, Serratia marcescens and Morganella morganii were collected at a Korean hospital. ESBL production was determined by double disk synergy test. For ESBL producers, bla genes were sequenced and blaCTX-M environment was characterized by PCR mapping and sequencing. Results: Among the 250 isolates 29 (11.6%) produced ESBL, and 14 of the 29 isolates produced CTX-M ESBLs, including CTX-M-9 by 8 isolates, CTX-M-3 by 4 isolates, CTX-M-12 by 1 isolate, and CTX-M-14 by 1 isolate. ISEcp1 was present upstream of blaCTX-M-3, 12, and 14. Three of the four CTXM-3 producers had the same genetic environment (pemK-ISEcp1-blaCTX-M-3-orf477-mucA). An IS903-like element was found downstream of blaCTX-M-14. ISCR1 was identified upstream of blaCTX-M-9 and ISCR1 and blaCTX-M-9 were located on sul1-type class 1 integron. The variable region between the 5’-CS and the first 3’-CS contained dfrA16 and aadA2. Its structure was similar to that of In60, but our isolates did not have IS3000 or second 3’-CS. Conclusion: CXT-M type ESBL was prevalent in AmpC β-lactamase-producing Enterobacteriaceae, particularly E. cloacae. blaCTX-M genes were associated with ISEcp1 or ISCR1. This is the first report on the genetic environment of blaCTX-M in Korean isolates. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 90~97 | - |
dc.relation.isPartOf | Korean Journal of Clinical Microbiology (대한임상미생물학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 염색체성 AmpC β-lactamase 생성 Enterobacteriaceae 균종에서의 CTX-M형 extended-spectrum β-lactamase 검출과 분자유전학적 특성 규명 | - |
dc.title.alternative | Detection of CTX-M-Type Extended-Spectrum β-Lactamase in Clinical Isolates of Chromosomal AmpC β-Lactamase-Producing Enterobacteriaceae from Korea and Their Molecular Characteristics | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | 김창기 | - |
dc.contributor.googleauthor | 염종화 | - |
dc.contributor.googleauthor | 용동은 | - |
dc.contributor.googleauthor | 정석훈 | - |
dc.contributor.googleauthor | 이경원 | - |
dc.contributor.googleauthor | 정윤섭 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01038 | - |
dc.contributor.localId | A02352 | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A03619 | - |
dc.contributor.localId | A03679 | - |
dc.relation.journalcode | J01984 | - |
dc.identifier.pmid | Extended-spectrum β-lactamase ; CTXM ; Genetic characteristics | - |
dc.subject.keyword | Extended-spectrum β-lactamase | - |
dc.subject.keyword | CTXM | - |
dc.subject.keyword | Genetic characteristics | - |
dc.contributor.alternativeName | Kim, Chang Ki | - |
dc.contributor.alternativeName | Yum, Jong Hwa | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.alternativeName | Chong, Yun Sop | - |
dc.contributor.affiliatedAuthor | Kim, Chang Ki | - |
dc.contributor.affiliatedAuthor | Yum, Jong Hwa | - |
dc.contributor.affiliatedAuthor | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Chong, Yun Sop | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 90 | - |
dc.citation.endPage | 97 | - |
dc.identifier.bibliographicCitation | Korean Journal of Clinical Microbiology (대한임상미생물학회지), Vol.11(2) : 90-97, 2008 | - |
dc.identifier.rimsid | 35513 | - |
dc.type.rims | ART | - |
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