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Clostridium difficile 독소 A와 B를 검출하는 신속진단키트(tox A/B quik chek)의 유용성 평가

Other Titles
 Evaluation of Rapid Assay (Toc A/B Quik Chek) for the Detection of Clostridium difficile Toxins A and B 
Authors
 김수정  ;  김희정  ;  김명숙  ;  고은미  ;  김창기  ;  정석훈  ;  정윤섭  ;  이경원 
Citation
 Korean Journal of Clinical Microbiology (대한임상미생물학회지), Vol.11(2) : 112-116, 2008 
Journal Title
 Korean Journal of Clinical Microbiology (대한임상미생물학회지) 
ISSN
 1229-0025 
Issue Date
2008
Keywords
Clostridium difficile ; Enzyme immunoassay ; Clostridium difficile Toxin A ; Clostridium difficile Toxin B
Abstract
Background: Toxin immunoassay is widely used for rapid diagnosis of Clostridium difficile-associated diarrhea. The aim of this study was to evaluate the performance of Tox A/B Quik Chek test (TECHLAB, Blacksburg, VA, USA) compared to toxigenic culture. Methods: From September 2006 to August 2007, 959 stools were examined by Tox A/B Quik Chek test and toxigenic culture (C. difficile culture plus tcdB PCR using colonies obtained from culture). Results: Compared to the results of toxigenic culture, the sensitivity and specificity of Tox A/B Quik Chek test were 47.5% and 97.5%, respectively. Conclusion: The sensitivity of Tox A/B Quik Chek test was not high, but the specificity was high. Although Tox A/B Quik Chek test alone is not sufficient to diagnose Clostridium difficile-associated diarrhea, it may aid rapid diagnosis, early treatment and prevention of nosocomial spread of the infection, if supplemented by C. difficile culture or tissue culture cytotoxin assay.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Eun Mi(고은미)
Kim, Chang Ki(김창기)
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Chong, Yun Sop(정윤섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108356
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