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Immunogenicity and safety of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine in healthy infants in Korea

Authors
 Dong Soo Kim  ;  Taek Jin Lee  ;  Jin Han Kang  ;  Jong-Hyun Kim  ;  Jung Hyun Lee  ;  Sang Hyuk Ma  ;  Sun Young Kim  ;  Hwang Min Kim  ;  Son Mun Shin 
Citation
 PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol.27(2) : 177-178, 2008 
Journal Title
 PEDIATRIC INFECTIOUS DISEASE JOURNAL 
ISSN
 0891-3668 
Issue Date
2008
MeSH
Animals ; Antibodies, Viral/blood ; Cattle ; Double-Blind Method ; Humans ; Infant ; Korea ; Reassortant Viruses/immunology* ; Rotavirus/immunology ; Rotavirus Vaccines/adverse effects* ; Rotavirus Vaccines/immunology*
Keywords
rotavirus ; rotavirus vaccine ; safety ; immunogenicity ; gastroenteritis
Abstract
We evaluated the immunogenicity and safety of pentavalent human-bovine reassortant rotavirus vaccine in 178 Korean healthy infants. Seroresponse rate for serum antirotavirus IgA titers was 94.7% among 94 vaccine recipients, as compared with 13.5% among 52 placebo recipients. Seroresponse rates in serum neutralizing antibody to each human rotavirus serotype in the vaccine were significantly higher in the vaccine group than in the placebo group. This vaccine was generally well tolerated and immunogenic.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006454-200802000-00017&LSLINK=80&D=ovft
DOI
10.1097/INF.0b013e31815aba79
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108323
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