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AAV-GAD gene for rat models of neuropathic pain and Parkinson's disease

Authors
 Kim J  ;  Yoon YS  ;  Lee H  ;  Chang JW 
Citation
 Acta Neurochirurgica Supplements, Vol.101 : 99-105, 2008 
Journal Title
Acta Neurochirurgica Supplements
ISSN
 0065-1419 
Issue Date
2008
MeSH
Adenoviridae/physiology* ; Animals ; Disease Models, Animal ; Genetic Therapy/methods* ; Glutamate Decarboxylase/genetics ; Glutamate Decarboxylase/therapeutic use* ; Humans ; Neuralgia/therapy* ; Parkinson Disease/therapy* ; Rats
Keywords
Gene therapy ; adeno-associated virus ; glutamate decarboxylase 65 ; parkinson’s disease ; neuropathic pain
Abstract
The introduction of therapeutic genes to neurons by genetic modification has potential as an effective treatment for CNS disorders for all that a successful clinical application has not yet been fully implemented. In this paper, we will discussed the role of AAV vectors with the GAD65 gene for animal models of PD and neuropathic pain. AAV vector is one of the most attractive gene delivery vehicles for direct introduction of therapeutic genes into the CNS in the treatment of neurological diseases. GAD65 is present as a membrane-associated form in synapses and is primarily involved in producing synaptic gamma-aminobutyric acid (GABA) for vesicular release. We constructed rAAV-GAD65 expressing rat GAD65 and demonstrated that rat Parkinsonian symptoms can be significantly improved concomitantly with the production of GAD65. We also demonstrated rAAV-GAD65 as a successful gene delivery vehicle in a chronic pain model by administrating rAAV-GAD65 to DRGs because GABA driven by GAD is a major inhibitory neurotransmitter in the dorsal horn of the spinal cord and also plays an important role in the ventral horn. We believe that AAV vectors can be excellent candidates for gene therapy of neurological diseases.
Full Text
http://link.springer.com/chapter/10.1007%2F978-3-211-78205-7_17
DOI
18642642
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Young Sul(윤영설)
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108310
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