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The prognostic significance of pathologic stage T0 on organ-confined bladder transitional cell carcinoma following radical cystectomy.

Authors
 Kang Su Cho  ;  Joo Wan Seo  ;  Sung Yul Park  ;  Nam Hoon Cho  ;  Young Deuk Choi  ;  Seung Choul Yang  ;  Sung Joon Hong 
Citation
 UROLOGIA INTERNATIONALIS, Vol.81(4) : 394-398, 2008 
Journal Title
 UROLOGIA INTERNATIONALIS 
ISSN
 0042-1138 
Issue Date
2008
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Transitional Cell/diagnosis* ; Carcinoma, Transitional Cell/pathology ; Carcinoma, Transitional Cell/surgery* ; Cystectomy/methods* ; Female ; Humans ; Male ; Medical Oncology/methods ; Middle Aged ; Prognosis ; Recurrence ; Retrospective Studies ; Treatment Outcome ; Urinary Bladder Neoplasms/diagnosis* ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery*
Keywords
Bladder cancer ; Transitional cell carcinoma ; Radical cystectomy ; Staging ; Prognosis
Abstract
INTRODUCTION: We evaluated the prognostic significance of pT0 stage on organ-confined transitional cell carcinoma of the bladder following radical cystectomy. PATIENTS AND METHODS: We retrospectively reviewed the medical records of consecutive patients who underwent radical cystectomy for organ-confined transitional cell carcinoma of the bladder between 1986 and 2004. Patients who were treated with neoadjuvant or adjuvant therapy were excluded. A total of 197 patients were enrolled in this study. We investigated the impact of pathologic T stage on disease-specific survival. RESULTS: Overall disease-specific survival rate was 84.1% after 5 years. Five-year disease-specific survival rates according to pathologic stage were 88.7% in pT0, 92.2% in pTis-1 and 65.4% in pT2 disease. Overall disease-specific survival rate with pTis-1 or pT0 tumors was significantly higher than with pT2 tumors (p = 0.001, pT2 vs. pT0; p < 0.001, pT2 vs. pTis-1), but there was no difference in disease-specific survival between pTis-1 and pT0 tumors (p > 0.05). In the muscle-invasive tumor group, pT0 tumors had a more favorable prognosis than pT2 tumors (p = 0.042), but there was no difference in prognosis between pT0 and pTis-1 tumors. CONCLUSIONS: Pathologic stage T0 cystectomy can be considered a curative therapy in most cases, including pT0cT2 tumors, but there is a substantial risk of tumor recurrence.
Full Text
http://www.karger.com/Article/FullText/167835
DOI
10.1159/000167835
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Park, Sung Yul(박성열)
Yang, Seung Choul(양승철)
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108255
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