0 339

Cited 0 times in

The prognosis and survival analysis according to seven staging systems of hepatocellular carcinoma following curative resection

Authors
 Choi SB  ;  Lee JG  ;  Kim KS  ;  Yoon DS  ;  Choi JS  ;  Lee WJ  ;  Kim BR 
Citation
 HEPATO-GASTROENTEROLOGY, Vol.55(88) : 2140-2145, 2008 
Journal Title
 HEPATO-GASTROENTEROLOGY 
ISSN
 0172-6390 
Issue Date
2008
MeSH
Aged ; Carcinoma, Hepatocellular/classification ; Carcinoma, Hepatocellular/mortality* ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery* ; Disease-Free Survival ; Female ; Humans ; Liver Neoplasms/classification ; Liver Neoplasms/mortality* ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery* ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging/classification ; Prognosis ; Retrospective Studies ; Survival Analysis
Keywords
Aged ; Carcinoma, Hepatocellular/classification ; Carcinoma, Hepatocellular/mortality* ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery* ; Disease-Free Survival ; Female ; Humans ; Liver Neoplasms/classification ; Liver Neoplasms/mortality* ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery* ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging/classification ; Prognosis ; Retrospective Studies ; Survival Analysis
Abstract
BACKGROUND/AIMS: Several staging systems have been introduced to predict the prognosis of hepatocellular carcinoma (HCC). The aim of current study was to analyze the clinicopathologic prognostic variables and calculate overall survival and disease-free survival rates to compare the prognosis of HCC patients treated with curative resection according to seven different staging systems. METHODOLOGY: A retrospective study of 163 patients with HCC who underwent curative resection in our department between January 1998 and December 2001 was conducted. The clinicopathological prognostic factors were identified by univariate analysis. The patients were classified according to the TNM (AJCC 5th and 6th edition), Okuda, BCLC (Barcelona Clinic Liver Cancer), JIS (Japanese Integrated System), CLIP (Cancer of Liver Italian Program), and GRETCH (Group d'Etude de Traitement du Carcinoma Hepatocellullarire) systems. The overall survival and disease free survival were calculated using the Kaplan-Meier method. RESULTS: Univariate analysis of clinicopathologic prognostic factors indicated that tumor size, satellite nodules, portal vein invasion, bile duct invasion, microvessel invasion, differentiation and albumin level were statistically significant factors for survival. Mean survival time was 72.3+/-3.0 months. The overall survival curve and the disease-free survival curve applied to TNM (AJCC 6th edition) staging clearly show the difference in survival. CONCLUSIONS: The TNM (AJCC 6th edition) staging system provides the most effective means of assessing the prognosis of patients following curative resection of HCC.
DOI
19260493
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Byong Ro(김병로)
Yoon, Dong Sup(윤동섭) ORCID logo https://orcid.org/0000-0001-6444-9606
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Lee, Jae Gil(이재길) ORCID logo https://orcid.org/0000-0002-1148-8035
Choi, Sae Byeol(최새별)
Choi, Jin Sub(최진섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108253
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse