Kwangwoo Chun ; Song-Kyu Park ; Hwan Mook Kim ; Yongseok Choi ; Myung-Hwa Kim ; Chun-Ho Park ; Bo-Young Joe ; Tae Gyu Chun ; Hyun-Moo Choi ; Hee-Yoon Lee ; Sung Hee Hong ; Myung Sook Kim ; Ky-Youb Nam ; Gyoonhee Han
A series of coumarin types MMP inhibitors were designed based on gelastatin hydroxamates (1) and evaluated for TACE, cellular TNF-alpha, and NO inhibitory activities. Among them, compounds 9b had potent inhibitory activities in enzymatic and cellular assays and good selectivity to MMP-2 and MMP-9. Further investigation of 9b will be carried out for its efficacy in RA animal model system.