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Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation

DC Field Value Language
dc.contributor.author김명화-
dc.date.accessioned2015-05-19T17:28:26Z-
dc.date.available2015-05-19T17:28:26Z-
dc.date.issued2008-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/108214-
dc.description.abstractA series of coumarin types MMP inhibitors were designed based on gelastatin hydroxamates (1) and evaluated for TACE, cellular TNF-alpha, and NO inhibitory activities. Among them, compounds 9b had potent inhibitory activities in enzymatic and cellular assays and good selectivity to MMP-2 and MMP-9. Further investigation of 9b will be carried out for its efficacy in RA animal model system.-
dc.description.statementOfResponsibilityopen-
dc.format.extent530~535-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHADAM Proteins/antagonists & inhibitors-
dc.subject.MESHADAM17 Protein-
dc.subject.MESHCoumarins*-
dc.subject.MESHHydroxamic Acids-
dc.subject.MESHMatrix Metalloproteinase Inhibitors-
dc.subject.MESHMetalloendopeptidases/antagonists & inhibitors*-
dc.subject.MESHNitric Oxide/antagonists & inhibitors-
dc.subject.MESHProtease Inhibitors/chemical synthesis*-
dc.subject.MESHProtease Inhibitors/pharmacology-
dc.subject.MESHStructure-Activity Relationship-
dc.subject.MESHTumor Necrosis Factor-alpha/antagonists & inhibitors-
dc.titleChromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorKwangwoo Chun-
dc.contributor.googleauthorSong-Kyu Park-
dc.contributor.googleauthorHwan Mook Kim-
dc.contributor.googleauthorYongseok Choi-
dc.contributor.googleauthorMyung-Hwa Kim-
dc.contributor.googleauthorChun-Ho Park-
dc.contributor.googleauthorBo-Young Joe-
dc.contributor.googleauthorTae Gyu Chun-
dc.contributor.googleauthorHyun-Moo Choi-
dc.contributor.googleauthorHee-Yoon Lee-
dc.contributor.googleauthorSung Hee Hong-
dc.contributor.googleauthorMyung Sook Kim-
dc.contributor.googleauthorKy-Youb Nam-
dc.contributor.googleauthorGyoonhee Han-
dc.identifier.doi10.1016/j.bmc.2007.09.014-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00430-
dc.relation.journalcodeJ00325-
dc.identifier.eissn1464-3391-
dc.identifier.pmid17936631-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0968089607007869-
dc.subject.keywordTNF-a converting enzyme (TACE)-
dc.subject.keywordMetalloproteinase-2(MMP-2)-
dc.subject.keywordMetalloproteinase-9 (MMP-9)-
dc.subject.keywordRheumatoid arthritis (RA)-
dc.subject.keywordGelastatin hydroxamates-
dc.subject.keywordCoumarin derivatives-
dc.contributor.alternativeNameKim, Myung Hwa-
dc.contributor.affiliatedAuthorKim, Myung Hwa-
dc.rights.accessRightsnot free-
dc.citation.volume16-
dc.citation.number1-
dc.citation.startPage530-
dc.citation.endPage535-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, Vol.16(1) : 530-535, 2008-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
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