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Echogenic carotid artery plaques are associated with vertebral fractures in postmenopausal women with low bone mass.

 Se Hwa Kim  ;  Yoo Mee Kim  ;  Mi Ae Cho  ;  Yumie Rhee  ;  Kyu Yeon Hur  ;  Eun Seok Kang  ;  Bong Soo Cha  ;  Eun Jig Lee  ;  Hyun Chul Lee  ;  Sung Kil Lim 
 CALCIFIED TISSUE INTERNATIONAL, Vol.82(6) : 411-417, 2008 
Journal Title
Issue Date
Aged ; Atherosclerosis/complications* ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/epidemiology ; Bone Density ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/pathology ; Carotid Stenosis/complications* ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/epidemiology ; Comorbidity ; Dyslipidemias/blood ; Endosonography ; Hip Joint/diagnostic imaging ; Hip Joint/metabolism ; Humans ; Hypertension/epidemiology ; Hypertension/pathology ; Korea/epidemiology ; Logistic Models ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/injuries ; Lumbar Vertebrae/metabolism ; Middle Aged ; Osteoporosis, Postmenopausal/complications* ; Osteoporosis, Postmenopausal/epidemiology ; Osteoporosis, Postmenopausal/metabolism ; Radiography ; Risk Factors ; Spinal Fractures/complications* ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/pathology ; Thoracic Vertebrae/diagnostic imaging ; Thoracic Vertebrae/injuries
Carotid atherosclerosis ; Echogenic plaque ; Vertebral fracture ; Bone mineral density ; Low bone mass
Although low bone mass has been associated with atherosclerosis even after adjustment for age, little is known about the association between vertebral fractures and calcified atherosclerotic plaques. Our objective was to investigate whether osteoporotic vertebral fractures are independently related to the prevalence of atherosclerotic carotid plaques in postmenopausal women with low bone mass. We enrolled 195 postmenopausal women with osteopenia or osteoporosis. Bone mineral density and the presence of vertebral fractures were assessed. Intima media thickness and atherosclerotic plaques of the carotid artery were assessed using ultrasonography. Of the 195 subjects in the study, 84 had no plaques and 111 had at least one. The percentage of women with vertebral fractures was significantly higher in subjects with echogenic carotid plaques than in those without (27% vs. 11%, respectively; P < 0.05). However, there was no difference in the prevalence of vertebral fractures between women with echolucent plaques and those without (10.9% vs. 10.7%, respectively; P = nonsignificant). By logistic regression analysis with multivariate adjustment, age (P < 0.01), dyslipidemia (P < 0.05), and the presence of vertebral fracture (P < 0.05) were independent risk factors for echogenic carotid plaques. Osteoporotic vertebral fractures are associated with an increased risk of echogenic atherosclerotic plaques in postmenopausal women with low bone mass. It appears that the high association of echogenic atherosclerotic plaques and vertebral fractures could partially explain why osteoporotic vertebral fractures are linked to increased mortality
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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