Cited 0 times in
Novel Calcium Phosphate Glass for Hard-Tissue Regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이용근 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2015-05-19T17:25:31Z | - |
dc.date.available | 2015-05-19T17:25:31Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 2093-2278 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108122 | - |
dc.description.abstract | Purpose: The aim of this review is to introduce a novel bone-graft material for hard-tissue regeneration based on the calcium phosphate glass(CPG). Materials and Methods: CPG was synthesized by melting and subsequent quenching process in the system of CaO-$CaF_2-P_2O_5$-MgO-ZnO having a much lower Ca/P ratio than that of conventional calcium phosphates such as HA or TCP. The biodegradability and bioactivity were performed. Effects on the proliferation, calcification and mineralization of osteoblast-like cells were examined in vitro. Influence in new bone and cementum formations was investigated in vivo using calvarial defects of Sprague-Dawley rats as well as 1-wall intrabony defect of beagle dogs. The application to the tissue-engineered macroporous scaffold and in vitro and in vivo tests was explored. Results: The extent of dissolution decreased with increasing Ca/P ratio. Exposure to either simulated body fluid or fetal bovine serum caused precipitation on the surface. The calcification and mineralization of osteoblast-like cells were enhanced by CPG. CPG promoted new bone and cementum formation in the calvarial defect of Sprague-Dawley rats after 8 weeks. The macroporous scaffolds can be fabricated with $500{\sim}800{\mu}m$ of pore size and a three-dimensionally interconnected open pore system. The stem cells were seeded continuously proliferated in CPG scaffold. Extracellular matrix and the osteocalcin were observed at the $2^{nd}$ days and $4^{th}$ week. A significant difference in new bone and cementum formations was observed in vivo (p<0.05). Conclusion: The novel calcium phosphate glass may play an integral role as potential biomaterial for regeneration of new bone and cementum. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 273~298 | - |
dc.relation.isPartOf | Journal of Korean Academy of Periodontology (대한치주과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Novel Calcium Phosphate Glass for Hard-Tissue Regeneration | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Dental Engineering (치과생체재료공학) | - |
dc.contributor.googleauthor | Yong-Keun Lee | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.identifier.doi | 10.5051/jkape.2008.38.Suppl.273 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02976 | - |
dc.contributor.localId | A04081 | - |
dc.relation.journalcode | J01492 | - |
dc.identifier.pmid | calcium phosphate; bone-graft; biodegradable | - |
dc.subject.keyword | calcium phosphate | - |
dc.subject.keyword | bone-graft | - |
dc.subject.keyword | biodegradable | - |
dc.contributor.alternativeName | Lee, Yong Keun | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Lee, Yong Keun | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 38 | - |
dc.citation.number | 2 suppl | - |
dc.citation.startPage | 273 | - |
dc.citation.endPage | 298 | - |
dc.identifier.bibliographicCitation | Journal of Korean Academy of Periodontology (대한치주과학회지), Vol.38(2 suppl) : 273-298, 2008 | - |
dc.identifier.rimsid | 35197 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.