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Cited 4 times in

8번 염색체 사체성을 보인 급성단구성백혈병 1예

Other Titles
 Tetrasomy 8 in a Patient with Acute Monoblastic Leukemia 
Authors
 김주원  ;  박태성  ;  송재우  ;  이경아  ;  이상국  ;  정준원  ;  최종락 
Citation
 KOREAN JOURNAL OF LABORATORY MEDICINE , Vol.28(4) : 262-266, 2008 
Journal Title
 KOREAN JOURNAL OF LABORATORY MEDICINE 
ISSN
 1598-6535 
Issue Date
2008
Keywords
Acute myelogenous leukemia ; Tetrasomy 8 ; Poor prognosis
Abstract
Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.
Files in This Item:
T200803290.pdf Download
DOI
10.3343/kjlm.2008.28.4.262
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Chung, Joo Won(정주원)
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108091
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