353 517

Cited 21 times in

Changes in cerebral glucose metabolism in patients with Parkinson disease with dementia after cholinesterase inhibitor therapy

Authors
 Phil Hyu Lee  ;  Seok Woo Yong  ;  Young-Sil An 
Citation
 JOURNAL OF NUCLEAR MEDICINE, Vol.49(12) : 2006-2011, 2008 
Journal Title
JOURNAL OF NUCLEAR MEDICINE
ISSN
 0161-5505 
Issue Date
2008
MeSH
Aged ; Aged, 80 and over ; Antiparkinson Agents/administration & dosage ; Brain/drug effects ; Brain/metabolism* ; Cholinesterase Inhibitors/administration & dosage* ; Dementia/complications ; Dementia/diagnostic imaging ; Dementia/drug therapy* ; Dementia/metabolism* ; Female ; Fluorodeoxyglucose F18/pharmacokinetics* ; Humans ; Male ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/drug therapy* ; Parkinson Disease/metabolism* ; Radionuclide Imaging ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution/drug effects ; Treatment Outcome
Keywords
Aged ; Aged, 80 and over ; Antiparkinson Agents/administration & dosage ; Brain/drug effects ; Brain/metabolism* ; Cholinesterase Inhibitors/administration & dosage* ; Dementia/complications ; Dementia/diagnostic imaging ; Dementia/drug therapy* ; Dementia/metabolism* ; Female ; Fluorodeoxyglucose F18/pharmacokinetics* ; Humans ; Male ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/drug therapy* ; Parkinson Disease/metabolism* ; Radionuclide Imaging ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution/drug effects ; Treatment Outcome
Abstract
We investigated changes in cerebral glucose metabolism after cholinesterase inhibitor (ChEI) therapy in patients with Parkinson disease dementia (PDD) to determine whether cognitive improvements would be reflected in changes of cerebral metabolic patterns, thus offering insight into the neural substrate of cognitive dysfunction in patients with PDD.

METHODS:

We performed a serial PET study before (baseline) and after ChEI therapy on 10 patients with PDD, using statistical parametric mapping. Additionally, covariance analysis was performed to extract regions in which increased change in regional cerebral metabolism correlated significantly with increased Mini-Mental State Examination scores.

RESULTS:

The statistical parametric mapping analysis indicated that significantly increased cerebral metabolism after ChEI therapy, compared with at baseline, was most evident in the left angular gyrus extending to the supramarginal area and left superior and middle frontal gyri. Additionally, cerebral metabolism was significantly increased in the right superior frontal and left middle orbitofrontal gyri. In contrast, the right fusiform gyrus showed significantly decreased metabolism after ChEI, compared with at baseline. In the correlation analysis, improvements in Mini-Mental State Examination scores after ChEI treatment were significantly associated with increased cerebral metabolism in the left supramarginal, orbitofrontal, and cingulate areas.

CONCLUSION:

Our data suggest that prefrontal and parietal association areas may be relevant structures for the pharmacologic response to ChEI in patients with PDD.
Files in This Item:
T200803147.pdf Download
DOI
10.2967/jnumed.108.054668
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108080
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links