6 272

Cited 27 times in

Influence of age and visceral fat area on plasma adiponectin concentrations in women with normal glucose tolerance

Authors
 Soo Jeong Koh  ;  Yae Jung Hyun  ;  So Yeon Choi  ;  Jey Sook Chae  ;  Ji Young Kim  ;  Sungha Park  ;  Chul-Min Ahn  ;  Yangsoo Jang  ;  Jong Ho Lee 
Citation
 CLINICA CHIMICA ACTA, Vol.389(1-2) : 45-50, 2008 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2008
MeSH
Abdominal Fat* ; Adiponectin/blood* ; Adult ; Age Factors* ; Body Composition ; Female ; Glucose Tolerance Test* ; Humans ; Inflammation Mediators/blood ; Middle Aged
Keywords
Adiponectin ; Age ; Visceral fat area ; Women
Abstract
BACKGROUND: Age-related adiponectin concentration has been discrepantly reported. We investigated the distribution of adiponectin by age in healthy women with normal glucose tolerance (NGT) and the relationship of adiponectin with visceral fat area (VFA). METHODS: Three-hundred fifty-nine women (age: 38+/-0.6 years, BMI: 26.5+/-0.2 kg/m(2)) were categorized into 4 age-groups: 20-29, 30-39, 40-49, and 50-64 years. Computed tomography was performed to measure abdominal fat area and adiponectin, TNF-alpha, interleukin-6 (IL-6), CRP, insulin, free fatty acid (FFA), and blood urea nitrogen (BUN) were determined. RESULTS: No significant differences were observed in BMI, total body fat percent and concentrations of insulin, IL-6 and CRP among age-groups. Waist circumference, total fat area at L4, and FFA were significantly higher only in postmenopausal women than in previous decades of premenopausal women. VFA, adiponectin and TNF-alpha concentrations are significantly higher in older women than in younger women. Higher adiponectin concentration in older women was clearly shown even after adjustment for VFA (P<0.05). Age per se was positively correlated with plasma adiponectin concentrations (r=0.21, P<0.001) and these relationship became stronger (r=0.36, P<0.001) after controlled for VFA. VFA was negatively correlated with adiponectin (r=-0.16, P<0.01) in total studied population. However, when analyzed subgroups separately, a strong negative correlation (r=-0.37, P<0.001) was found in younger women (<40 years), while a weak significant relationship (r=-0.18, P<0.05) was found in older women (> or =40 years). In a multiple stepwise regression model to predict adiponectin, only age and VFA remained in the model at P<0.001. CONCLUSIONS: We observed a significant positive relationship between plasma adiponectin and age, even after adjustment for visceral adiposity. These associations suggest that adiponectin concentrations are affected by visceral adiposity, with additional independent effects of age
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898107005700
DOI
10.1016/j.cca.2007.11.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Ahn, Chul-Min(안철민) ORCID logo https://orcid.org/0000-0002-7071-4370
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108010
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse