소아 간질환자에서의 삶의 질과 Topiramate

Abstract

Summary: The primary goal of epilepsy treatment is to enhance patients’ quality of life (QOL) including medical, psychosocial and cognitive function as well as control of seizure. We reviewed the literatures on the objective methods to evaluate QOL and several risk factors for QOL outcome of antiepileptic drug (AED), especially topiramate. Several factors such as age, increased seizure severity, low socioeconomic state, longer duration of AED treatment, side-effect of AED, polytherapy and refractory epilepsy were related to low QOL. Topiramate significantly reduces seizure frequency and improves quality of life including energy/fatigue, anxiety, self-esteem, concentration, memory, language, cognition, social activity, behavior problem and general health in childhood epilepsy.