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Incidence and clinical behavior of papillary thyroid carcinoma in renal allograft recipients: a single center experience

Authors
 J. Lee  ;  J.J. Jeong  ;  Y.S. Lee  ;  K.H. Nam  ;  H.S. Chang  ;  W.Y. Chung  ;  E.Y. Soh  ;  Y.S. Kim  ;  C.S. Park 
Citation
 TRANSPLANTATION PROCEEDINGS, Vol.40(10) : 3751-3754, 2008 
Journal Title
TRANSPLANTATION PROCEEDINGS
ISSN
 0041-1345 
Issue Date
2008
MeSH
Adolescent ; Adult ; Aged ; Carcinoma, Papillary/epidemiology* ; Carcinoma, Papillary/pathology ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Kidney Transplantation/adverse effects* ; Male ; Middle Aged ; Neoplasms/epidemiology* ; Prevalence ; Retrospective Studies ; Thyroid Hormones/blood ; Thyroid Neoplasms/epidemiology* ; Thyroid Neoplasms/pathology ; Transplantation, Homologous/adverse effects ; Young Adult
Keywords
Adolescent ; Adult ; Aged ; Carcinoma, Papillary/epidemiology* ; Carcinoma, Papillary/pathology ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Kidney Transplantation/adverse effects* ; Male ; Middle Aged ; Neoplasms/epidemiology* ; Prevalence ; Retrospective Studies ; Thyroid Hormones/blood ; Thyroid Neoplasms/epidemiology* ; Thyroid Neoplasms/pathology ; Transplantation, Homologous/adverse effects ; Young Adult
Abstract
The chronic use of immunosuppressive therapy in transplant recipients increases the long-term risk for carcinoma. However, there is insufficient knowledge regarding the incidence and biological behavior of papillary thyroid carcinomas (PTC) in renal allograft recipients. In the present study we examined the incidence and biological behavior of PTCs among 1739 patients transplanted between January 1986 and December 1999 who had been followed for a mean period of 137 months (range, 84-238 months). During the follow-up, 129 (7.4%) recipients were identified to display posttransplantation malignancies, including 12 (0.7%) with PTCs. The 6 male and 6 female patients had a mean age of 41 years (range, 23-57 years). Nine cases (incidentalomas) were diagnosed based on ultrasonographic (US) screening. Eight of those 9 were TNM stage I, 2 of the 3 clinical carcinomas were TNM stage IVa. During a mean follow-up of 94 months (range, 18-159 months), 2 (16.7%) PTC patients developed locoregional recurrence, but no patients showed distant metastases. These data showed that recipients had a higher incidence of PTC compared with the general Korean population (0.7% vs 0.02%). Posttransplantation PTC tended to show no difference in gender distribution, and was often associated with aggressive lymphatic metastasis. However, most incidentalomas showed favorable treatment outcomes. In conclusion, routine surveillance of the thyroid gland using US screening is recommended to ensure early detection, treatment, and favorable prognosis of PTC.
Full Text
http://www.sciencedirect.com/science/article/pii/S0041134508010105
DOI
10.1016/j.transproceed.2008.07.127
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Park, Cheong Soo(박정수)
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Chung, Woong Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107864
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