Cited 14 times in
Comparison of combination posterior sub-tenon triamcinolone and modified grid laser treatment with intravitreal triamcinolone treatment in patients with diffuse diabetic macular edema.
DC Field | Value | Language |
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dc.contributor.author | 고형준 | - |
dc.date.accessioned | 2015-05-19T17:16:10Z | - |
dc.date.available | 2015-05-19T17:16:10Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107825 | - |
dc.description.abstract | PURPOSE: To compare the efficacy of posterior sub-Tenon's capsule triamcinolone acetonide injection combined with modified grid macular photocoagulation (PSTI + MP) with intravitreal triamcinolone acetonide (IVTA) injection in the treatment of diffuse diabetic macular edema (DME). MATERIALS AND METHODS: Forty eyes of 33 patients with diffuse DME were randomly allocated into either PSTI + MP (20 eyes) or IVTA (20 eyes). Best corrected visual acuity (VA) and foveal thickness were measured. RESULTS: The ETDRS scores at baseline were 25.2 +/- 13.6 (mean +/- SD) letters in the PSTI + MP group, whereas 21.7 +/- 16.3 letters in the IVTA group. The ETDRS scores improved by 33.2 +/- 15.9, 34.7 +/- 16.6 and 30.9 +/- 19.0 letters in the PSTI + MP group whereas by 30.9 +/- 15.4, 30.1 +/- 17.9 and 31.5 +/- 15.0 letters in the IVTA group at 1, 3, and 6 months after the treatments, respectively. The VA improved significantly at 1 month and 3 months after both treatments (all p < 0.02, paired t-test). The VA improvements were no longer significant at 6 months in either group. There were no statistically significant differences at any time points between the 2 groups (all p > 0.05, Student's t-test). The foveal thicknesses at baseline and 1, 3, and 6 months after the treatments were 382.8 +/- 148.3, 309.1 +/- 131.3, 319.3 +/- 93.3, 340.4 +/- 123.5 microm (mean +/- SD) in the PSTI + MP group vs. 369.1 +/- 123.1, 241.4 +/- 52.3, 277.5 +/- 137.4, 290.2 +/- 127.9microm in the IVTA group, respectively. Pairwise comparisons revealed significant decrease in foveal thickness at 1 month (p = 0.01, paired t-test) for the PSTI + MP group, and at both 1 month (p < 0.001) and 3 months (p = 0.016) for the IVTA group. There were no statistically significant differences at any time points between the 2 groups (all p > 0.05, Student's t-test). In contrast to the PSTI + MP group, where no complications were noted, the elevation of intra-ocular pressure in 3 of 20 eyes (15%) and a significant increase in average cataract grading were observed in the IVTA group. CONCLUSION: PSTI + MP treatment provides significant improvement of vision in patients with diffuse DME over 3 months, and achieves outcomes comparable to those after IVTA treatment, however, with fewer complications. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 955~965 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anti-Inflammatory Agents/administration & dosage | - |
dc.subject.MESH | Diabetic Retinopathy/drug therapy* | - |
dc.subject.MESH | Diabetic Retinopathy/physiopathology | - |
dc.subject.MESH | Diabetic Retinopathy/surgery* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fovea Centralis/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Laser Coagulation* | - |
dc.subject.MESH | Macular Edema/complications | - |
dc.subject.MESH | Macular Edema/drug therapy* | - |
dc.subject.MESH | Macular Edema/physiopathology | - |
dc.subject.MESH | Macular Edema/surgery* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Triamcinolone/administration & dosage* | - |
dc.subject.MESH | Visual Acuity | - |
dc.subject.MESH | Vitreous Body | - |
dc.title | Comparison of combination posterior sub-tenon triamcinolone and modified grid laser treatment with intravitreal triamcinolone treatment in patients with diffuse diabetic macular edema. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Eun Jee Chung | - |
dc.contributor.googleauthor | William R. Freeman | - |
dc.contributor.googleauthor | Stanley P. Azen | - |
dc.contributor.googleauthor | Hyo Lee | - |
dc.contributor.googleauthor | Hyoung Jun Koh | - |
dc.identifier.doi | 10.3349/ymj.2008.49.6.955 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00152 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 19108019 | - |
dc.subject.keyword | Diabetic macular edema | - |
dc.subject.keyword | combined treatment | - |
dc.subject.keyword | intravitreal triamcinolone injection | - |
dc.subject.keyword | posterior sub-Tenon triamcinolone injection | - |
dc.contributor.alternativeName | Koh, Hyoung Jun | - |
dc.contributor.affiliatedAuthor | Koh, Hyoung Jun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 49 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 955 | - |
dc.citation.endPage | 965 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.49(6) : 955-965, 2008 | - |
dc.identifier.rimsid | 34709 | - |
dc.type.rims | ART | - |
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