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The effects of different beta-blockers on left-ventricular volume and function after primary coronary stenting in acute myocardial infarction

Authors
 Sang-Hak Lee  ;  Seong-Bo Yoon  ;  Jung-Rae Cho  ;  Seonghoon Choi  ;  Jae-Hun Jung  ;  Namho Lee 
Citation
 ANGIOLOGY, Vol.59(6) : 676-681, 2008 
Journal Title
 ANGIOLOGY 
ISSN
 0003-3197 
Issue Date
2008
MeSH
Adrenergic beta-Antagonists/therapeutic use* ; Aged ; Angioplasty, Balloon, Coronary/instrumentation* ; Blood Pressure/drug effects ; Carbazoles/therapeutic use* ; Carvedilol ; Female ; Heart Rate/drug effects ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/drug effects* ; Heart Ventricles/physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Infarction/drug therapy ; Myocardial Infarction/physiopathology ; Myocardial Infarction/therapy* ; Propanolamines/therapeutic use* ; Propranolol/therapeutic use* ; Retrospective Studies ; Stents* ; Stroke Volume/drug effects ; Time Factors ; Treatment Outcome ; Ultrasonography ; Ventricular Function, Left/drug effects*
Keywords
[beta]-adrenergic blockers ; carvedilol ; ventricular remodeling ; ventricular ejection fraction ; myocardial infarction
Abstract
The beneficial effect of beta-blockers is reported in myocardial infarction (MI). This study compared the effects of propranolol and carvedilol on left-ventricular (LV) volume and function after acute MI. Serial echocardiographic studies were performed on acute MI patients who were treated with primary coronary stenting and medical treatment, including propranolol or carvedilol. Determinants of the changes in LV volume and function were identified by regression analyses. At 6 months, there was no significant difference in change in the LV end-diastolic volume between patients receiving 2 beta-blockers. The increase of LV ejection fraction was greater in patients receiving carvedilol. On multivariate analyses, it was found that the kind of beta-blocker had no significant influence on the changes in LV volume or ejection fraction, whereas gender and baseline LV ejection fraction were predictive of change in LV ejection fraction. Compared with propranolol, carvedilol did not have a significant benefit on LV remodeling or function after primary coronary stenting in acute MI.
Full Text
http://ang.sagepub.com/content/59/6/676
DOI
10.1177/0003319708315303
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107823
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