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Relationship of angiogenic factors to disease activity and radiographic damage in rheumatoid arthritis

Authors
 M.-C. Park  ;  S.-J. Chung  ;  Y.-B. Park  ;  S.-K. Lee 
Citation
 Clinical and Experimental Rheumatology, Vol.26(5) : 881-886, 2008 
Journal Title
 Clinical and Experimental Rheumatology 
ISSN
 0392-856X 
Issue Date
2008
MeSH
Angiogenesis Inducing Agents/blood* ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Arthritis, Rheumatoid/blood* ; Arthritis, Rheumatoid/diagnostic imaging* ; Arthritis, Rheumatoid/genetics ; Case-Control Studies ; Endoglin ; Fibroblasts/metabolism ; Humans ; Inhibitor of Apoptosis Proteins ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Leukocytes, Mononuclear/immunology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Osteoarthritis/genetics ; RNA, Messenger/immunology ; RNA, Messenger/metabolism ; Radiography ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Ribonuclease, Pancreatic/genetics ; Ribonuclease, Pancreatic/metabolism ; Severity of Illness Index ; Survivin ; Synovial Membrane/metabolism
Keywords
Angiogenesis Inducing Agents/blood* ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Arthritis, Rheumatoid/blood* ; Arthritis, Rheumatoid/diagnostic imaging* ; Arthritis, Rheumatoid/genetics ; Case-Control Studies ; Endoglin ; Fibroblasts/metabolism ; Humans ; Inhibitor of Apoptosis Proteins ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Leukocytes, Mononuclear/immunology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Osteoarthritis/genetics ; RNA, Messenger/immunology ; RNA, Messenger/metabolism ; Radiography ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Ribonuclease, Pancreatic/genetics ; Ribonuclease, Pancreatic/metabolism ; Severity of Illness Index ; Survivin ; Synovial Membrane/metabolism
Abstract
OBJECTIVE: To determine the association between angiogenic factor mRNA expression and disease activity and radiographic damage in patients with rheumatoid arthritis (RA). METHODS: We enrolled 42 RA patients and assessed their disease activity (DAS28) and Larsen scores. We used a semi-quantitative reverse transcriptase-polymerase chain reaction to measure levels of angiogenin, endoglin, survivin and angiomotin mRNA in peripheral blood mononuclear cells (PBMCs) from 42 patients and in fibroblasts-like synoviocytes (FLS) from 14 RA patients. Then, we compared the angiogenic factor mRNA expression levels and parameters for disease activity and radiographic damage between RA patients and 42 healthy controls. We also compared the mRNA levels from FLS between 14 RA patients and 12 osteoarthritis (OA) patients. RESULTS: PBMCs from RA patients showed increased expression of survivin and angiomotin mRNA compared to controls, while rheumatoid FLS showed increased expression for all genes tested compared to OA FLS. Angiogenin, endoglin, and angiomotin mRNA levels of PBMCs did not show any significant correlation with DAS28, but the survivin mRNA level in PBMCs showed a significant positive correlation with DAS28 (p=0.003) and Larsen scores (p=0.012). Survivin was the only angiogenic factor that showed a significant association with the Larsen score. CONCLUSION: The systemic and local production of angiogenic factors are increased in patients with RA and, of the genes tested in this study, survivin gene expression correlated well with disease activity and radiographic damage in patients with RA.
Full Text
http://www.clinexprheumatol.org/abstract.asp?a=3501
DOI
19032823
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Min Chan(박민찬) ORCID logo https://orcid.org/0000-0003-1189-7637
Park, Yong Beom(박용범)
Lee, Soo Kon(이수곤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107815
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