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Helicobacter pylori eradication therapy may facilitate gastric ulcer healing after endoscopic mucosal resection: a prospective randomized study

Authors
 Jae Hee Cheon  ;  Jie-Hyun Kim  ;  Sang Kil Lee  ;  Tae Il Kim  ;  Won Ho Kim  ;  Yong Chan Lee 
Citation
 HELICOBACTER, Vol.13(6) : 564-571, 2008 
Journal Title
 HELICOBACTER 
ISSN
 1083-4389 
Issue Date
2008
MeSH
2-Pyridinylmethylsulfinylbenzimidazoles/administration & dosage ; Aged ; Amoxicillin/administration & dosage ; Anti-Bacterial Agents/administration & dosage ; Anti-Ulcer Agents/administration & dosage ; Clarithromycin/administration & dosage ; Female ; Gastroscopy/adverse effects* ; Helicobacter Infections/drug therapy* ; Helicobacter pylori/drug effects* ; Humans ; Iatrogenic Disease* ; Lansoprazole ; Male ; Middle Aged ; Prospective Studies ; Severity of Illness Index ; Stomach Neoplasms/complications* ; Stomach Neoplasms/surgery ; Stomach Ulcer/drug therapy* ; Treatment Outcome
Keywords
Helicobacter pylori ; eradication ; iatrogenic ulcer ; endoscopic mucosal resection
Abstract
BACKGROUND AND AIM: It remains unclear whether Helicobacter pylori eradication therapy affects the healing rate of iatrogenic ulcers following endoscopic mucosal resection (EMR) for gastric tumors. The aim of our study was to prospectively evaluate the effect of H. pylori eradication therapy on gastric ulcer healing after EMR. METHODS: After EMR, patients were randomly assigned to either the H. pylori eradication group (Hp group) (lansoprazole 30 mg, amoxicillin 1000 mg, and clarithromycin 500 mg, twice a day for 7 days) or the noneradication group (proton pump inhibitor, PPI group) (lansoprazole 30 mg, twice a day for 7 days). Four weeks after EMR, the ulcer stages and size were compared between the two groups. Moreover, ulcer-related symptoms, bleeding rates, adverse effects, and drug compliance were compared. RESULTS: A total of 64 patients were enrolled. Of these, 17 patients were excluded from the study. The two groups were comparable in terms of baseline clinicopathologic characteristics. Four weeks after EMR, the two groups did not differ with respect to ulcer stage (p = .475) or ulcer-related symptoms (p = .399). However, the ulcer reduction ratio was significantly higher in the Hp group (0.028 +/- 0.024 vs. 0.065 +/- 0.055, p < .05). No differences were observed between the two groups with regard to drug compliance, adverse drug event rates, or bleeding rates. CONCLUSIONS: Our results suggest that H. pylori eradication therapy might improve the ulcer healing rate after EMR
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1523-5378.2008.00647.x/abstract
DOI
10.1111/j.1523-5378.2008.00647.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107789
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