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파킨슨병 환자에서 양측 시상밑부 뇌심부자극의 효과 : 신촌 세브란스 병원의 6개월 추적 관찰 결과

Other Titles
 The Effect of Bilateral Subthalamic Nucleus Stimulation in Parkinson’s Disease: Experiences From 6 Month Follow-up in Sinchon Severance Hospital 
Authors
 신혜원  ;  장진우  ;  손영호 
Citation
 Journal of the Korean Neurological Association, Vol.26(2) : 110-117, 2008 
Journal Title
Journal of the Korean Neurological Association
ISSN
 1225-7044 
Issue Date
2008
Keywords
Parkinson disease ; Deep brain stimulation ; Subthalamic nucleus ; Short-term effects
Abstract
Background: Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known as an effective
neurosurgical procedure for the treatment of advanced Parkinson disease (PD). Although short- and long-term
effects of STN stimulation in PD are relatively well known, an interim analysis of its efficacy is essential for us
to continue with this procedure in the future. We present the clinical outcome of 6 month follow-up in patients
who were assessed in our hospital after bilateral STN stimulation.
Methods: Twenty-nine patients with PD treated with bilateral STN DBS were included in this study. The effect
of STN DBS was assessed at 6 months after surgery, which included the followings; motor disability in ‘DBS-
off/on, medication-off/on’ states, activity of daily living (ADL) in ‘medication-off/on’ states, levodopa-induced motor
complication, daily levodopa and levodopa-equivalent dosage, neuropsychological assessment and quality of life.
Results: Nineteen patients completed the follow-up assessment. STN stimulation produced significant improve-
ments in the motor disability score both during ‘medication-off’ and ‘medication-on’ states. The ADL score was
improved only in ‘medication-off’ states. The amount of levodopa-induced dyskinesia and response fluctuation
also significantly decreased. Scores of Korean version of Mini-mental status examination (K-MMSE), Korean
version of Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K) and Beck Depression Inventory
(BDI) did not change. Daily levodopa and levodopa-equivalent dosages were significantly reduced. No serious
side effect was encountered.
Conclusions: Bilateral STN DBS is a relatively safe and beneficial treatment for PD patients with levodopa-
induced motor complications. In order to obtain a better prognosis in the future, we should assess the long-term
outcome and the clinical predictive factors of STN DBS.
Files in This Item:
T200801417.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107730
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