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뇌종자세포종(Intracranial Germinoma)의 치료에 있어 방사선 단독 치료와 방사선 및 약물 병용 치료군에서의 방사선 용량 비교

Other Titles
 Comparison of Dose between Radiotherapy Alone and Concurrent Radio-chemotherapy in Treatment of Intracranial Germinoma 
Authors
 김범식  ;  권승연  ;  한정우  ;  서창옥  ;  심규원  ;  김동석  ;  최중언  ;  원성철  ;  유철주 
Citation
 Clinical Pediatric Hematology-Oncology, Vol.15(2) : 118-126, 2008 
Journal Title
 Clinical Pediatric Hematology-Oncology (임상소아혈액종양) 
ISSN
 1225-6978 
Issue Date
2008
Keywords
Intracranial germinoma ; Germ cell tumor ; Craniospinal irradiation ; Chemotherapy
Abstract
Purpose: Intracranial germinoma is the most frequent intracranial germ cell tumor. Radiotherapy has so far been considered as the standard treatment. Radiotherapy could unfavorably affect the quality of life, so there have been many trials to reduce the radiation dose. We report significant reduction of radiation dose on tumor field when it was combined with chemotherapy. Methods: From January 1997 to January 2007, 31 patients were enrolled in this study. 12 patients received radiotherapy alone, 19 patients received radio-chemotherapy. We compared craniospinal irradiation (CSI) dose, total irradiation dose on tumor bed and incidence of CSI between two groups. Results: There were 21 male and 10 female patients, with a mean age of 19.3 years. Solitary tumors were found in 26 cases (83.9%), multiple tumors in 5 cases (16.1%). All patients were survived. The average CSI dose in radiotherapy alone group was 18.88±6.18 Gy and that of radio-chemotherapy group was 13.25±9.54 Gy. CSI dose in radiotherapy alone group was higher than that of radio-chemotherapy group (P=0.002). The average total radiation dose in radiotherapy alone group was 38.98±2.71 Gy and that of radio-chemotherapy group was 33.87±5.55 Gy. The total irradiation dose in radiotherapy alone group was also higher than that of radio-chemotherapy group (P=0.001). The incidence of CSI was higher in radiotherapy alone group (P<0.05). Conclusion: We discovered that there was a significant reduction of radiation dose in radio- chemotherapy group. It suggested that we could reduce the radiation dose in treatment of intracranial germinoma when we combine chemotherapy with radiation therapy, which could reduce the side effects of radiation.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Seung Yeon(권승연)
Kim, Dong Seok(김동석)
Suh, Chang Ok(서창옥)
Shim, Kyu Won(심규원) ORCID logo https://orcid.org/0000-0002-9441-7354
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
Han, Jung Woo(한정우) ORCID logo https://orcid.org/0000-0001-8936-1205
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/107707
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